eF-site ID 3zbf-A PDB Code 3zbf Chain A click to enlarge Title Structure of Human ROS1 Kinase Domain in Complex with Crizotinib Classification TRANSFERASE Compound PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS Source (ROS1_HUMAN) Sequence A:  IENLPAFPREKLTLRLLLGSGEVYEGTAVDILGVGSGEIK VAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVC LLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDL VDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPR IVKIGDFGLARDIYLPVRWMAPESLMDGIFTTQSDVWSFG ILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPD DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYK SR Description Functional site 1) chain A residue 1978 type sequence A description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 2) chain A residue 2010 type sequence L description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 3) chain A residue 2027 type sequence E description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 4) chain A residue 2029 type sequence M description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 5) chain A residue 2032 type sequence G description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 6) chain A residue 2033 type sequence D description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 7) chain A residue 2083 type sequence R description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 8) chain A residue 2084 type sequence N description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 9) chain A residue 2086 type sequence L description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 10) chain A residue 2101 type sequence G description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 11) chain A residue 2102 type sequence D description BINDING SITE FOR RESIDUE VGH A 3000 source : AC1 12) chain A residue 1951-1980 type prosite sequence LGSGEVYEGTAVDILGVGSGEIKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGAFGEVYeGtavdilgvgsgeik....VAVK source prosite : PS00107 13) chain A residue 2075-2087 type prosite sequence FIHRDLAARNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV source prosite : PS00109 14) chain A residue 2079 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 1951 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 1980 type BINDING sequence K description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI3

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