eF-site ID 3x0b-B PDB Code 3x0b Chain B click to enlarge Title Crystal structure of PIP4KIIBETA I368A complex with AMP Classification TRANSFERASE Compound Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Source Homo sapiens (Human) (PI42B_HUMAN) Sequence B:  KVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDF KAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFG IDDQDYQNSVTRSAPINRFLTTYDRRFVIKTVSSEDVAEM HNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVV TRNVFSHRLTVHRKYDLKAREASDKEKAKDLPTFKDNDFL NEGQKHVSKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDV DRAEQRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIAD ILTNPEQYSKRFNEFMSNILT Description Functional site 1) chain B residue 96 type sequence K description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 2) chain B residue 98 type sequence Y description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 3) chain B residue 154 type sequence S description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 4) chain B residue 157 type sequence V description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 5) chain B residue 158 type sequence A description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 6) chain B residue 161 type sequence H description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 7) chain B residue 188 type sequence R description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 8) chain B residue 197 type sequence Y description BINDING SITE FOR RESIDUE AMP A 502 source : AC2 9) chain B residue 139 type sequence F description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 10) chain B residue 148 type sequence V description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 11) chain B residue 150 type sequence K description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 12) chain B residue 203 type sequence N description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 13) chain B residue 204 type sequence V description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 14) chain B residue 205 type sequence F description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 15) chain B residue 216 type sequence D description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 16) chain B residue 282 type sequence L description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 17) chain B residue 369 type sequence D description BINDING SITE FOR RESIDUE AMP B 501 source : AC4 18) chain B residue 202 type BINDING sequence R description BINDING => ECO:0000305|PubMed:26774281, ECO:0007744|PDB:3X03 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 203 type BINDING sequence N description BINDING => ECO:0000305|PubMed:26774281, ECO:0007744|PDB:3X04 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 214 type BINDING sequence K description BINDING => ECO:0000305|PubMed:26774281, ECO:0007744|PDB:3X04 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 369 type BINDING sequence D description BINDING => ECO:0000305|PubMed:26774281, ECO:0007744|PDB:3X04 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 94 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P48426 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 150 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 150 type catalytic sequence K description 662 source MCSA : MCSA2 25) chain B residue 278 type catalytic sequence D description 662 source MCSA : MCSA2

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