eF-site ID 3wzu-A PDB Code 3wzu Chain A click to enlarge Title THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Dual specificity mitogen-activated protein kinase kinase 7 Source Homo sapiens (Human) (MP2K7_HUMAN) Sequence A:  GYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTG HVIAVKQMRRSGNKVVLKSHDCPYIVQCFGTFITNTDVFI AMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLK EKHGVIHRDVKPSNILLDERGQIKLCDFGAGCAAYMAPER IDPPPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVL TKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYN KLLEHSFIKRYETLEVDVASWFKDVMAKTE Description Functional site 1) chain A residue 142 type sequence M description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 2) chain A residue 143 type sequence G description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 3) chain A residue 145 type sequence G description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 4) chain A residue 146 type sequence T description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 5) chain A residue 165 type sequence K description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 6) chain A residue 212 type sequence M description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 7) chain A residue 213 type sequence E description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 8) chain A residue 215 type sequence M description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 9) chain A residue 218 type sequence C description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 10) chain A residue 221 type sequence K description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 11) chain A residue 263 type sequence S description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 12) chain A residue 266 type sequence L description BINDING SITE FOR RESIDUE 1FM A 600 source : AC1 13) chain A residue 259 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 142 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 165 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 255-267 type prosite sequence VIHRDVKPSNILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNILL source prosite : PS00108

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