eF-site ID 3wsq-AHL
PDB Code 3wsq
Chain A, H, L

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Title Structure of HER2 with an Fab
Classification TRANSFERASE/IMMUNE SYSTEM
Compound Receptor tyrosine-protein kinase erbB-2
Source Homo sapiens (Human) (3WSQ)
Sequence A:  TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLEL
TYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
RGTQLFEDNYALAVLDNGDPLSPGGLRELQLRSLTEILKG
GVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRA
CHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPL
PTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPAL
VTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSC
TLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLR
EVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAP
LQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVI
RGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHN
THLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLAC
HQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLP
REYVNARHCLPCHPECQPQNGSVTCFGPEADQCVA
H:  EVQLVQSGGGLKVPGGSVKVSCKASSYTFTSYGISWVRQA
PGQGLEWMGDVNTYAGNTNYAQKLQGRVTMTTDTGTSTAY
MELRSLRSDDAAVYYCARDRGYYAFDIWGQGTMVTVSSAS
TKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI
CNVNHKPSNTKVDKKVEP
L:  QSVLTQPPSASGTPGQTVTLSCSGSRTNAGRDPVSWYQQL
PGTAPKLLTSTAPQGPSGVPDRFSGSKSGTSSSLAISGLQ
SGDEADYYCTVWDSVPGASVFGSGTFLTVTVAAPSVFIFP
PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ
GLSSPVTKSFNRGEC
Description (1)  Receptor tyrosine-protein kinase erbB-2 (E.C.2.7.10.1), Antibody Light Chain, Antibody Heavy Chain


Functional site

1) chain A
residue 165
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85
source Swiss-Prot : SWS_FT_FI4

2) chain A
residue 237
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0000269|PubMed:20696930, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW, ECO:0007744|PDB:3N85
source Swiss-Prot : SWS_FT_FI5

3) chain A
residue 508
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0007744|PDB:1S78
source Swiss-Prot : SWS_FT_FI6

4) chain A
residue 549
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:3MZW
source Swiss-Prot : SWS_FT_FI7

5) chain A
residue 46
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW
source Swiss-Prot : SWS_FT_FI2

6) chain A
residue 160
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI1

7) chain L
residue 193-199
type prosite
sequence YACEVTH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
source prosite : PS00290

8) chain H
residue 199-205
type prosite
sequence YICNVNH
description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
source prosite : PS00290


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