eF-site ID 3wpt-AB PDB Code 3wpt Chain A, B click to enlarge Title Crystal structure of closed dimer of human importin-alpha1 (Rch1) Classification TRANSPORT PROTEIN Compound Importin subunit alpha-1 Source Homo sapiens (Human) (IMA1_HUMAN) Sequence A:  NWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDN IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQ TKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWA ISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQ KEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDT KIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE ALQNHENESVYKASLSLIEKYF B:  NWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDN IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQ TKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWA ISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQ KEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDT KIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE ALQNHENESVYKASLSLIEKYFS Description Functional site 1) chain A residue 456 type sequence E description BINDING SITE FOR RESIDUE PEG A 501 source : AC1 2) chain A residue 367 type sequence Q description BINDING SITE FOR RESIDUE PEG A 502 source : AC2 3) chain A residue 410 type sequence V description BINDING SITE FOR RESIDUE PEG A 502 source : AC2 4) chain A residue 388 type sequence K description BINDING SITE FOR RESIDUE PEG A 503 source : AC3 5) chain A residue 389 type sequence A description BINDING SITE FOR RESIDUE PEG A 503 source : AC3 6) chain A residue 391 type sequence F description BINDING SITE FOR RESIDUE PEG A 503 source : AC3 7) chain A residue 394 type sequence Q description BINDING SITE FOR RESIDUE PEG A 503 source : AC3 8) chain A residue 227 type sequence R description BINDING SITE FOR RESIDUE PEG A 504 source : AC4 9) chain B residue 391 type sequence F description BINDING SITE FOR RESIDUE PEG A 504 source : AC4 10) chain A residue 224 type sequence G description BINDING SITE FOR RESIDUE PEG A 505 source : AC5 11) chain B residue 391 type sequence F description BINDING SITE FOR RESIDUE PEG A 505 source : AC5 12) chain B residue 430 type sequence T description BINDING SITE FOR RESIDUE PEG A 505 source : AC5 13) chain B residue 431 type sequence A description BINDING SITE FOR RESIDUE PEG A 505 source : AC5 14) chain B residue 432 type sequence K description BINDING SITE FOR RESIDUE PEG A 505 source : AC5 15) chain A residue 306 type sequence E description BINDING SITE FOR RESIDUE PEG A 506 source : AC6 16) chain A residue 238 type sequence R description BINDING SITE FOR RESIDUE PEG A 508 source : AC7 17) chain A residue 273 type sequence W description BINDING SITE FOR RESIDUE PEG A 508 source : AC7 18) chain A residue 277 type sequence Y description BINDING SITE FOR RESIDUE PEG A 508 source : AC7 19) chain A residue 241 type sequence N description BINDING SITE FOR RESIDUE PEG A 509 source : AC8 20) chain B residue 152 type sequence S description BINDING SITE FOR RESIDUE PEG A 509 source : AC8 21) chain A residue 391 type sequence F description BINDING SITE FOR RESIDUE PEG A 510 source : AC9 22) chain A residue 432 type sequence K description BINDING SITE FOR RESIDUE PEG A 510 source : AC9 23) chain B residue 227 type sequence R description BINDING SITE FOR RESIDUE PEG A 510 source : AC9 24) chain A residue 353 type sequence K description BINDING SITE FOR RESIDUE PEG A 511 source : BC1 25) chain A residue 354 type sequence E description BINDING SITE FOR RESIDUE PEG A 511 source : BC1 26) chain A residue 357 type sequence W description BINDING SITE FOR RESIDUE PEG A 511 source : BC1 27) chain A residue 396 type sequence E description BINDING SITE FOR RESIDUE PEG A 511 source : BC1 28) chain B residue 315 type sequence R description BINDING SITE FOR RESIDUE PEG B 501 source : BC2 29) chain B residue 396 type sequence E description BINDING SITE FOR RESIDUE PEG B 501 source : BC2 30) chain A residue 152 type sequence S description BINDING SITE FOR RESIDUE PEG B 502 source : BC3 31) chain B residue 240 type sequence K description BINDING SITE FOR RESIDUE PEG B 502 source : BC3 32) chain A residue 240 type sequence K description BINDING SITE FOR RESIDUE PEG B 503 source : BC4 33) chain B residue 149 type sequence S description BINDING SITE FOR RESIDUE PEG B 503 source : BC4 34) chain B residue 150 type sequence G description BINDING SITE FOR RESIDUE PEG B 503 source : BC4 35) chain B residue 152 type sequence S description BINDING SITE FOR RESIDUE PEG B 503 source : BC4 36) chain B residue 414 type sequence V description BINDING SITE FOR RESIDUE PEG B 504 source : BC5 37) chain B residue 456 type sequence E description BINDING SITE FOR RESIDUE PEG B 504 source : BC5 38) chain B residue 459 type sequence K description BINDING SITE FOR RESIDUE PEG B 504 source : BC5 39) chain B residue 371 type sequence Q description BINDING SITE FOR RESIDUE PEG B 505 source : BC6 40) chain B residue 330 type sequence V description BINDING SITE FOR RESIDUE PEG B 506 source : BC7 41) chain A residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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