eF-site ID 3wcz-A PDB Code 3wcz Chain A click to enlarge Title Crystal structure of Bombyx mori aldo-keto reductase (AKR2E4) in complex with NADP Classification OXIDOREDUCTASE Compound Aldo-keto reductase 2E Source Bombyx mori (Silk moth) (H9JTG9_BOMMO) Sequence A:  AVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAV YWAIEAGYRHIDTAAVYQDEEQVGQGIAEAIANGLVTREE LFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHF PIATKPDDSPDNIDYLETWQGMQDARQLGLARSIGVSNFN ATQITRLVSNSYIRPVINQIEVNPTNTQEPLVAHCQSLGI AVMAYSPFGFVVSRGQTGAPPPRSDDPTLTALANKYRKSV GQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEE VAAINQFNKNHRVIDISDWKDYPNYPN Description Functional site 1) chain A residue 22 type sequence G description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 2) chain A residue 23 type sequence T description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 3) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 4) chain A residue 27 type sequence T description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 5) chain A residue 29 type sequence K description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 6) chain A residue 53 type sequence D description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 7) chain A residue 58 type sequence Y description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 8) chain A residue 120 type sequence H description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 9) chain A residue 158 type sequence S description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 10) chain A residue 159 type sequence N description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 11) chain A residue 180 type sequence Q description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 12) chain A residue 206 type sequence Y description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 13) chain A residue 207 type sequence S description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 14) chain A residue 208 type sequence P description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 15) chain A residue 209 type sequence F description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 16) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 17) chain A residue 215 type sequence R description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 18) chain A residue 257 type sequence I description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 19) chain A residue 258 type sequence P description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 20) chain A residue 259 type sequence K description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 21) chain A residue 260 type sequence S description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 22) chain A residue 261 type sequence T description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 23) chain A residue 265 type sequence R description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 24) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE NAP A 401 source : AC1 25) chain A residue 173 type sequence Y description BINDING SITE FOR RESIDUE EDO A 402 source : AC2 26) chain A residue 174 type sequence I description BINDING SITE FOR RESIDUE EDO A 402 source : AC2 27) chain A residue 175 type sequence R description BINDING SITE FOR RESIDUE EDO A 402 source : AC2 28) chain A residue 15 type sequence T description BINDING SITE FOR RESIDUE EDO A 403 source : AC3 29) chain A residue 17 type sequence P description BINDING SITE FOR RESIDUE EDO A 403 source : AC3 30) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE EDO A 403 source : AC3 31) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE EDO A 403 source : AC3 32) chain A residue 82 type sequence L description BINDING SITE FOR RESIDUE EDO A 403 source : AC3 33) chain A residue 74 type sequence N description BINDING SITE FOR RESIDUE EDO A 404 source : AC4 34) chain A residue 76 type sequence L description BINDING SITE FOR RESIDUE EDO A 404 source : AC4 35) chain A residue 289 type sequence N description BINDING SITE FOR RESIDUE EDO A 404 source : AC4 36) chain A residue 291 type sequence N description BINDING SITE FOR RESIDUE EDO A 404 source : AC4 37) chain A residue 159 type sequence N description BINDING SITE FOR RESIDUE EDO A 405 source : AC5 38) chain A residue 189 type sequence Q description BINDING SITE FOR RESIDUE EDO A 405 source : AC5 39) chain A residue 192 type sequence L description BINDING SITE FOR RESIDUE EDO A 405 source : AC5 40) chain A residue 293 type sequence R description BINDING SITE FOR RESIDUE EDO A 405 source : AC5 41) chain A residue 308 type sequence N description BINDING SITE FOR RESIDUE EDO A 405 source : AC5 42) chain A residue 24 type sequence G description BINDING SITE FOR RESIDUE CIT A 406 source : AC6 43) chain A residue 25 type sequence R description BINDING SITE FOR RESIDUE CIT A 406 source : AC6 44) chain A residue 26 type sequence G description BINDING SITE FOR RESIDUE CIT A 406 source : AC6 45) chain A residue 58 type sequence Y description BINDING SITE FOR RESIDUE CIT A 406 source : AC6 46) chain A residue 22 type BINDING sequence G description BINDING => ECO:0000269|PubMed:24012638 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 53 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24012638 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 158 type BINDING sequence S description BINDING => ECO:0000269|PubMed:24012638 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 215 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24012638 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 259 type BINDING sequence K description BINDING => ECO:0000269|PubMed:24012638 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 58 type ACT_SITE sequence Y description Proton donor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 143-160 type prosite sequence MQDARQLGLARSIGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MqdarqlglARSIGVSNF source prosite : PS00062 53) chain A residue 257-272 type prosite sequence IPKSTNKQRIAQNIDL description ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSTNkqRIaQNiDL source prosite : PS00063 54) chain A residue 48-65 type prosite sequence GYRHIDTAAVYQDEEQVG description ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAavyqdEeqVG source prosite : PS00798

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