eF-site ID 3wa2-X PDB Code 3wa2 Chain X click to enlarge Title High resolution crystal structure of copper amine oxidase from arthrobacter globiformis Classification OXIDOREDUCTASE Compound Phenylethylamine oxidase Source Arthrobacter globiformis (PAOX_ARTGO) Sequence X:  ASPFRLASAGEISEVQGILRTAGLLGPEKRIAYLGVLDPA RGAGSEAEDRRFRVFIHDVSGARPQEVTVSVTNGTVISAV ELDTAATGELPVLEEEFEVVEQLLATDERWLKALAARNLD VSKVRVAPLSAGVFEYAEERGRRILRGLAFVQDFPEDSAW AHPVDGLVAYVDVVSKEVTRVIDTGVFPVPAEHGNYTDPE LTGPLRTTQKPISITQPEGPSFTVTGGNHIEWEKWSLDVG FDVREGVVLHNIAFRDGDRLRPIINRASIAEMVVPYGDPS PIRSWQNYFDTGEYLVGQYANSLELGCDCLGDITYLSPVI SDAFGNPREIRNGICMHEEDWGILAKHSDLWSGINYTRRN RRMVISFFTTIGNXDYGFYWYLYLDGTIEFEAKATGVVFT SAFPEGGSDNISQLAPGLGAPFHQHIFSARLDMAIDGFTN RVEEEDVVRQTMGPGNERGNAFSRKRTVLTRESEAVREAD ARTGRTWIISNPESKNRLNEPVGYKLHAHNQPTLLADPGS SIARRAAFATKDLWVTRYADDERYPTGDFVNQHSGGAGLP SYIAQDRDIDGQDIVVWHTFGLTHFPRVEDWPIMPVDTVG FKLRPEGFFDRSPVLDVPANP Description Functional site 1) chain X residue 431 type sequence H description BINDING SITE FOR RESIDUE CU X 701 source : AC1 2) chain X residue 433 type sequence H description BINDING SITE FOR RESIDUE CU X 701 source : AC1 3) chain X residue 592 type sequence H description BINDING SITE FOR RESIDUE CU X 701 source : AC1 4) chain X residue 440 type sequence D description BINDING SITE FOR RESIDUE NA X 702 source : AC2 5) chain X residue 441 type sequence M description BINDING SITE FOR RESIDUE NA X 702 source : AC2 6) chain X residue 581 type sequence D description BINDING SITE FOR RESIDUE NA X 702 source : AC2 7) chain X residue 582 type sequence I description BINDING SITE FOR RESIDUE NA X 702 source : AC2 8) chain X residue 41 type sequence Y description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 9) chain X residue 43 type sequence G description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 10) chain X residue 44 type sequence V description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 11) chain X residue 45 type sequence L description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 12) chain X residue 61 type sequence R description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 13) chain X residue 551 type sequence R description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 14) chain X residue 552 type sequence Y description BINDING SITE FOR RESIDUE EDO X 703 source : AC3 15) chain X residue 349 type sequence W description BINDING SITE FOR RESIDUE EDO X 705 source : AC5 16) chain X residue 351 type sequence I description BINDING SITE FOR RESIDUE EDO X 705 source : AC5 17) chain X residue 368 type sequence N description BINDING SITE FOR RESIDUE EDO X 705 source : AC5 18) chain X residue 393 type sequence D description BINDING SITE FOR RESIDUE EDO X 705 source : AC5 19) chain X residue 604 type sequence V description BINDING SITE FOR RESIDUE EDO X 705 source : AC5 20) chain X residue 287 type sequence P description BINDING SITE FOR RESIDUE EDO X 706 source : AC6 21) chain X residue 463 type sequence G description BINDING SITE FOR RESIDUE EDO X 706 source : AC6 22) chain X residue 465 type sequence E description BINDING SITE FOR RESIDUE EDO X 706 source : AC6 23) chain X residue 188 type sequence R description BINDING SITE FOR RESIDUE EDO X 707 source : AC7 24) chain X residue 29 type sequence T description BINDING SITE FOR RESIDUE EDO X 708 source : AC8 25) chain X residue 532 type sequence R description BINDING SITE FOR RESIDUE EDO X 708 source : AC8 26) chain X residue 535 type sequence A description BINDING SITE FOR RESIDUE EDO X 708 source : AC8 27) chain X residue 564 type sequence G description BINDING SITE FOR RESIDUE EDO X 708 source : AC8 28) chain X residue 568 type sequence P description BINDING SITE FOR RESIDUE EDO X 708 source : AC8 29) chain X residue 458 type sequence Q description BINDING SITE FOR RESIDUE EDO X 709 source : AC9 30) chain X residue 462 type sequence P description BINDING SITE FOR RESIDUE EDO X 709 source : AC9 31) chain X residue 463 type sequence G description BINDING SITE FOR RESIDUE EDO X 709 source : AC9 32) chain X residue 464 type sequence N description BINDING SITE FOR RESIDUE EDO X 709 source : AC9 33) chain X residue 363 type sequence N description BINDING SITE FOR RESIDUE EDO X 710 source : BC1 34) chain X residue 366 type sequence R description BINDING SITE FOR RESIDUE EDO X 710 source : BC1 35) chain X residue 43 type sequence G description BINDING SITE FOR RESIDUE EDO X 711 source : BC2 36) chain X residue 44 type sequence V description BINDING SITE FOR RESIDUE EDO X 711 source : BC2 37) chain X residue 249 type sequence F description BINDING SITE FOR RESIDUE EDO X 711 source : BC2 38) chain X residue 250 type sequence D description BINDING SITE FOR RESIDUE EDO X 711 source : BC2 39) chain X residue 471 type sequence S description BINDING SITE FOR RESIDUE EDO X 712 source : BC3 40) chain X residue 472 type sequence R description BINDING SITE FOR RESIDUE EDO X 712 source : BC3 41) chain X residue 413 type sequence E description BINDING SITE FOR RESIDUE EDO X 713 source : BC4 42) chain X residue 415 type sequence G description BINDING SITE FOR RESIDUE EDO X 713 source : BC4 43) chain X residue 117 type sequence R description BINDING SITE FOR RESIDUE EDO X 714 source : BC5 44) chain X residue 188 type sequence R description BINDING SITE FOR RESIDUE EDO X 714 source : BC5 45) chain X residue 189 type sequence V description BINDING SITE FOR RESIDUE EDO X 714 source : BC5 46) chain X residue 472 type sequence R description BINDING SITE FOR RESIDUE PEG X 715 source : BC6 47) chain X residue 485 type sequence R description BINDING SITE FOR RESIDUE PEG X 716 source : BC7 48) chain X residue 486 type sequence E description BINDING SITE FOR RESIDUE PEG X 716 source : BC7 49) chain X residue 488 type sequence D description BINDING SITE FOR RESIDUE PEG X 716 source : BC7 50) chain X residue 493 type sequence R description BINDING SITE FOR RESIDUE PEG X 716 source : BC7 51) chain X residue 195 type sequence F description BINDING SITE FOR RESIDUE PEG X 717 source : BC8 52) chain X residue 196 type sequence P description BINDING SITE FOR RESIDUE PEG X 717 source : BC8 53) chain X residue 412 type sequence P description BINDING SITE FOR RESIDUE PEG X 717 source : BC8 54) chain X residue 413 type sequence E description BINDING SITE FOR RESIDUE PEG X 717 source : BC8 55) chain X residue 135 type sequence A description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 56) chain X residue 168 type sequence W description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 57) chain X residue 356 type sequence S description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 58) chain X residue 357 type sequence D description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 59) chain X residue 358 type sequence L description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 60) chain X residue 359 type sequence W description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 61) chain X residue 378 type sequence T description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 62) chain X residue 380 type sequence G description BINDING SITE FOR RESIDUE PEG X 718 source : BC9 63) chain X residue 13 type sequence R description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 64) chain X residue 14 type sequence L description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 65) chain X residue 15 type sequence A description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 66) chain X residue 16 type sequence S description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 67) chain X residue 19 type sequence E description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 68) chain X residue 71 type sequence R description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 69) chain X residue 91 type sequence D description BINDING SITE FOR RESIDUE PEG X 719 source : CC1 70) chain X residue 627 type sequence A description BINDING SITE FOR RESIDUE PEG X 720 source : CC2 71) chain X residue 349 type sequence W description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 72) chain X residue 349 type sequence W description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 73) chain X residue 350 type sequence G description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 74) chain X residue 370 type sequence R description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 75) chain X residue 389 type sequence Y description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 76) chain X residue 397 type sequence E description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 77) chain X residue 399 type sequence E description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 78) chain X residue 401 type sequence K description BINDING SITE FOR RESIDUE PEG X 721 source : CC3 79) chain X residue 46 type sequence D description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 80) chain X residue 253 type sequence E description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 81) chain X residue 274 type sequence R description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 82) chain X residue 548 type sequence D description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 83) chain X residue 551 type sequence R description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 84) chain X residue 552 type sequence Y description BINDING SITE FOR RESIDUE PEG X 722 source : CC4 85) chain X residue 47 type sequence P description BINDING SITE FOR RESIDUE PEG X 723 source : CC5 86) chain X residue 49 type sequence R description BINDING SITE FOR RESIDUE PEG X 723 source : CC5 87) chain X residue 546 type sequence Y description BINDING SITE FOR RESIDUE PEG X 723 source : CC5 88) chain X residue 548 type sequence D description BINDING SITE FOR RESIDUE PEG X 723 source : CC5 89) chain X residue 551 type sequence R description BINDING SITE FOR RESIDUE PEG X 723 source : CC5 90) chain X residue 100 type sequence V description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 91) chain X residue 101 type sequence L description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 92) chain X residue 102 type sequence E description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 93) chain X residue 104 type sequence E description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 94) chain X residue 105 type sequence F description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 95) chain X residue 136 type sequence P description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 96) chain X residue 307 type sequence Y description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 97) chain X residue 378 type sequence T description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 98) chain X residue 379 type sequence I description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 99) chain X residue 380 type sequence G description BINDING SITE FOR RESIDUE PGE X 724 source : CC6 100) chain X residue 424 type sequence P description BINDING SITE FOR RESIDUE PGE X 725 source : CC7 101) chain X residue 505 type sequence R description BINDING SITE FOR RESIDUE PGE X 725 source : CC7 102) chain X residue 192 type sequence T description BINDING SITE FOR RESIDUE PGE X 726 source : CC8 103) chain X residue 194 type sequence V description BINDING SITE FOR RESIDUE PGE X 726 source : CC8 104) chain X residue 195 type sequence F description BINDING SITE FOR RESIDUE PGE X 726 source : CC8 105) chain X residue 208 type sequence E description BINDING SITE FOR RESIDUE PGE X 727 source : CC9 106) chain X residue 211 type sequence G description BINDING SITE FOR RESIDUE PGE X 727 source : CC9 107) chain X residue 619 type sequence R description BINDING SITE FOR RESIDUE PGE X 727 source : CC9 108) chain X residue 135 type sequence A description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 109) chain X residue 137 type sequence L description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 110) chain X residue 168 type sequence W description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 111) chain X residue 380 type sequence G description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 112) chain X residue 381 type sequence N description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 113) chain X residue 382 type sequence X description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 114) chain X residue 407 type sequence F description BINDING SITE FOR RESIDUE PGE X 728 source : DC1 115) chain X residue 126 type sequence N description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 116) chain X residue 128 type sequence D description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 117) chain X residue 161 type sequence D description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 118) chain X residue 170 type sequence H description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 119) chain X residue 197 type sequence V description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 120) chain X residue 199 type sequence A description BINDING SITE FOR RESIDUE PG4 X 729 source : DC2 121) chain X residue 402 type sequence A description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 122) chain X residue 433 type sequence H description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 123) chain X residue 590 type sequence L description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 124) chain X residue 592 type sequence H description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 125) chain X residue 593 type sequence F description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 126) chain X residue 595 type sequence R description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 127) chain X residue 598 type sequence D description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 128) chain X residue 602 type sequence M description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 129) chain X residue 603 type sequence P description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 130) chain X residue 605 type sequence D description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 131) chain X residue 612 type sequence R description BINDING SITE FOR RESIDUE 1PE X 730 source : DC3 132) chain X residue 189 type sequence V description BINDING SITE FOR RESIDUE 1PE X 731 source : DC4 133) chain X residue 191 type sequence D description BINDING SITE FOR RESIDUE 1PE X 731 source : DC4 134) chain X residue 192 type sequence T description BINDING SITE FOR RESIDUE 1PE X 731 source : DC4 135) chain X residue 156 type sequence L description BINDING SITE FOR RESIDUE OXY X 732 source : DC5 136) chain X residue 157 type sequence A description BINDING SITE FOR RESIDUE OXY X 732 source : DC5 137) chain X residue 172 type sequence V description BINDING SITE FOR RESIDUE OXY X 732 source : DC5 138) chain X residue 175 type sequence L description BINDING SITE FOR RESIDUE OXY X 732 source : DC5 139) chain X residue 399 type sequence E description BINDING SITE FOR RESIDUE OXY X 733 source : DC6 140) chain X residue 517 type sequence H description BINDING SITE FOR RESIDUE OXY X 733 source : DC6 141) chain X residue 606 type sequence T description BINDING SITE FOR RESIDUE OXY X 733 source : DC6 142) chain X residue 607 type sequence V description BINDING SITE FOR RESIDUE OXY X 733 source : DC6 143) chain X residue 487 type sequence A description BINDING SITE FOR RESIDUE OXY X 734 source : DC7 144) chain X residue 490 type sequence R description BINDING SITE FOR RESIDUE OXY X 734 source : DC7 145) chain X residue 521 type sequence T description BINDING SITE FOR RESIDUE OXY X 735 source : DC8 146) chain X residue 522 type sequence L description BINDING SITE FOR RESIDUE OXY X 735 source : DC8 147) chain X residue 538 type sequence T description BINDING SITE FOR RESIDUE OXY X 735 source : DC8 148) chain X residue 371-384 type prosite sequence MVISFFTTIGNXDY description COPPER_AMINE_OXID_1 Copper amine oxidase topaquinone signature. MVIsfftTigNYDY source prosite : PS01164 149) chain X residue 587-600 type prosite sequence TFGLTHFPRVEDWP description COPPER_AMINE_OXID_2 Copper amine oxidase copper-binding site signature. TfGltHFprvEDwP source prosite : PS01165 150) chain X residue 298 type ACT_SITE sequence D description Proton acceptor => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI1 151) chain X residue 382 type ACT_SITE sequence X description Schiff-base intermediate with substrate; via topaquinone => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI2 152) chain X residue 296 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P12807 source Swiss-Prot : SWS_FT_FI3 153) chain X residue 379 type BINDING sequence I description BINDING => ECO:0000250|UniProtKB:P46883 source Swiss-Prot : SWS_FT_FI4 154) chain X residue 431 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 155) chain X residue 433 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 156) chain X residue 592 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9405045, ECO:0007744|PDB:1AV4, ECO:0007744|PDB:1AVL, ECO:0007744|PDB:1IU7, ECO:0007744|PDB:1IVU, ECO:0007744|PDB:1IVV, ECO:0007744|PDB:1IVW, ECO:0007744|PDB:1IVX, ECO:0007744|PDB:1RJO, ECO:0007744|PDB:1SIH, ECO:0007744|PDB:1SII, ECO:0007744|PDB:1UI8, ECO:0007744|PDB:1W4N, ECO:0007744|PDB:1W5Z, ECO:0007744|PDB:1W6C, ECO:0007744|PDB:1W6G, ECO:0007744|PDB:2BT3, ECO:0007744|PDB:2CFD, ECO:0007744|PDB:2CFG, ECO:0007744|PDB:2CFK, ECO:0007744|PDB:2CFL, ECO:0007744|PDB:2CFW, ECO:0007744|PDB:2CG0, ECO:0007744|PDB:2CG1, ECO:0007744|PDB:2CWT, ECO:0007744|PDB:2CWU, ECO:0007744|PDB:2CWV, ECO:0007744|PDB:2D1W, ECO:0007744|PDB:2E2T, ECO:0007744|PDB:2E2U, ECO:0007744|PDB:2E2V, ECO:0007744|PDB:2YX9, ECO:0007744|PDB:2ZL8, ECO:0007744|PDB:3AMO, ECO:0007744|PDB:3KII, ECO:0007744|PDB:3KN4, ECO:0007744|PDB:3WA2, ECO:0007744|PDB:3WA3 source Swiss-Prot : SWS_FT_FI5 157) chain X residue 382 type MOD_RES sequence X description 2',4',5'-topaquinone => ECO:0000269|PubMed:9405045 source Swiss-Prot : SWS_FT_FI6

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