eF-site ID 3w8j-ABCD PDB Code 3w8j Chain A, B, C, D click to enlarge Title Crystal structure of P5 a0 in a complex with Prx4 c-term Classification OXIDOREDUCTASE/ISOMERASE Compound Protein disulfide-isomerase A6 Source Homo sapiens (Human) (PRDX4_MOUSE) Sequence A:  LYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHAQ RLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFP TIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRL G B:  MLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHA QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGF PTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDR LG C:  EVCPAG D:  EVCPAG Description (1)  Protein disulfide-isomerase A6 (E.C.5.3.4.1), C-terminal peptide from Peroxiredoxin-4 (E.C.1.11.1.15) Functional site 1) chain A residue 21 type sequence Y description BINDING SITE FOR RESIDUE K A 201 source : AC1 2) chain A residue 49 type sequence E description BINDING SITE FOR RESIDUE K A 201 source : AC1 3) chain A residue 58 type sequence A description BINDING SITE FOR RESIDUE K A 201 source : AC1 4) chain A residue 62 type sequence T description BINDING SITE FOR RESIDUE K A 201 source : AC1 5) chain A residue 22 type sequence S description BINDING SITE FOR RESIDUE K A 202 source : AC2 6) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE K A 202 source : AC2 7) chain A residue 27 type sequence V description BINDING SITE FOR RESIDUE K A 202 source : AC2 8) chain B residue 40 type sequence I description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 9) chain B residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 10) chain B residue 121 type sequence E description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 11) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 12) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 13) chain A residue 41 type sequence Q description BINDING SITE FOR RESIDUE GOL B 202 source : AC4 14) chain B residue 137 type sequence D description BINDING SITE FOR RESIDUE GOL B 202 source : AC4 15) chain B residue 83 type sequence A description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 16) chain B residue 95 type sequence V description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 17) chain B residue 98 type sequence F description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 18) chain D residue 5 type sequence G description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 19) chain B residue 96 type sequence Q description BINDING SITE FOR RESIDUE GOL B 204 source : AC6 20) chain B residue 20 type sequence L description BINDING SITE FOR RESIDUE K B 205 source : AC7 21) chain B residue 21 type sequence Y description BINDING SITE FOR RESIDUE K B 205 source : AC7 22) chain B residue 49 type sequence E description BINDING SITE FOR RESIDUE K B 205 source : AC7 23) chain B residue 58 type sequence A description BINDING SITE FOR RESIDUE K B 205 source : AC7 24) chain B residue 62 type sequence T description BINDING SITE FOR RESIDUE K B 205 source : AC7 25) chain B residue 22 type sequence S description BINDING SITE FOR RESIDUE K B 206 source : AC8 26) chain B residue 23 type sequence S description BINDING SITE FOR RESIDUE K B 206 source : AC8 27) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE K B 206 source : AC8 28) chain B residue 27 type sequence V description BINDING SITE FOR RESIDUE K B 206 source : AC8 29) chain A residue 55 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 58 type ACT_SITE sequence A description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 55 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 58 type ACT_SITE sequence A description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 56 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 57 type SITE sequence H description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 56 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 57 type SITE sequence H description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 118 type SITE sequence R description Lowers pKa of C-terminal Cys of first active site => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 118 type SITE sequence R description Lowers pKa of C-terminal Cys of first active site => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 129 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 129 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4

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