eF-site ID 3w8j-B PDB Code 3w8j Chain B click to enlarge Title Crystal structure of P5 a0 in a complex with Prx4 c-term Classification OXIDOREDUCTASE/ISOMERASE Compound Protein disulfide-isomerase A6 Source Homo sapiens (Human) (PRDX4_MOUSE) Sequence B:  MLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHA QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGF PTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDR LG Description (1)  Protein disulfide-isomerase A6 (E.C.5.3.4.1), C-terminal peptide from Peroxiredoxin-4 (E.C.1.11.1.15) Functional site 1) chain B residue 40 type sequence I description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 2) chain B residue 109 type sequence N description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 3) chain B residue 121 type sequence E description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 4) chain B residue 122 type sequence A description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 5) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE GOL B 201 source : AC3 6) chain B residue 137 type sequence D description BINDING SITE FOR RESIDUE GOL B 202 source : AC4 7) chain B residue 83 type sequence A description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 8) chain B residue 95 type sequence V description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 9) chain B residue 98 type sequence F description BINDING SITE FOR RESIDUE GOL B 203 source : AC5 10) chain B residue 96 type sequence Q description BINDING SITE FOR RESIDUE GOL B 204 source : AC6 11) chain B residue 20 type sequence L description BINDING SITE FOR RESIDUE K B 205 source : AC7 12) chain B residue 21 type sequence Y description BINDING SITE FOR RESIDUE K B 205 source : AC7 13) chain B residue 49 type sequence E description BINDING SITE FOR RESIDUE K B 205 source : AC7 14) chain B residue 58 type sequence A description BINDING SITE FOR RESIDUE K B 205 source : AC7 15) chain B residue 62 type sequence T description BINDING SITE FOR RESIDUE K B 205 source : AC7 16) chain B residue 22 type sequence S description BINDING SITE FOR RESIDUE K B 206 source : AC8 17) chain B residue 23 type sequence S description BINDING SITE FOR RESIDUE K B 206 source : AC8 18) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE K B 206 source : AC8 19) chain B residue 27 type sequence V description BINDING SITE FOR RESIDUE K B 206 source : AC8 20) chain B residue 55 type ACT_SITE sequence C description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 58 type ACT_SITE sequence A description Nucleophile => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 56 type SITE sequence G description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 57 type SITE sequence H description Contributes to redox potential value => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 118 type SITE sequence R description Lowers pKa of C-terminal Cys of first active site => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 129 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4

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