eF-site ID 3w68-ABCD PDB Code 3w68 Chain A, B, C, D click to enlarge Title Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(4,5)-bisphosphate Classification TRANSPORT PROTEIN Compound Alpha-tocopherol transfer protein Source Mus musculus (Mouse) (TTPA_MOUSE) Sequence A:  QPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLD LAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVL RSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIV QEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLT DSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHL HGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIM KSEDYLSSISE B:  LLQPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFD LDLAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHG VLRSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSEL IVQEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAV LTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRI HLHGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNF IMKSEDYLSSISE C:  PGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLDL AWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVLR SRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIVQ EVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLTD SFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLH GNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIMK SEDYLSSISETI D:  QPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLD LAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVL RSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIV QEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLT DSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHL HGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIM KSEDYLSSISE Description Functional site 1) chain A residue 129 type sequence A description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 2) chain A residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 3) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 4) chain A residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 5) chain A residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 6) chain A residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 7) chain A residue 183 type sequence L description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 8) chain A residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 9) chain A residue 208 type sequence S description BINDING SITE FOR RESIDUE 4PT A 302 source : AC2 10) chain A residue 211 type sequence K description BINDING SITE FOR RESIDUE 4PT A 302 source : AC2 11) chain A residue 219 type sequence K description BINDING SITE FOR RESIDUE 4PT A 302 source : AC2 12) chain B residue 172 type sequence T description BINDING SITE FOR RESIDUE 4PT A 302 source : AC2 13) chain A residue 190 type sequence K description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 14) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 15) chain A residue 215 type sequence T description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 16) chain A residue 217 type sequence K description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 17) chain A residue 218 type sequence I description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 18) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE 4PT A 303 source : AC3 19) chain B residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV B 301 source : AC4 20) chain B residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV B 301 source : AC4 21) chain B residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV B 301 source : AC4 22) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV B 301 source : AC4 23) chain B residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV B 301 source : AC4 24) chain A residue 168 type sequence A description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 25) chain A residue 171 type sequence I description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 26) chain A residue 172 type sequence T description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 27) chain A residue 173 type sequence P description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 28) chain B residue 208 type sequence S description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 29) chain B residue 209 type sequence M description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 30) chain B residue 211 type sequence K description BINDING SITE FOR RESIDUE PBU B 302 source : AC5 31) chain B residue 190 type sequence K description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 32) chain B residue 192 type sequence R description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 33) chain B residue 215 type sequence T description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 34) chain B residue 217 type sequence K description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 35) chain B residue 218 type sequence I description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 36) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE 4PT B 303 source : AC6 37) chain C residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 38) chain C residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 39) chain C residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 40) chain C residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 41) chain C residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 42) chain C residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 43) chain C residue 191 type sequence V description BINDING SITE FOR RESIDUE VIV C 301 source : AC7 44) chain C residue 217 type sequence K description BINDING SITE FOR RESIDUE PO4 C 302 source : AC8 45) chain C residue 221 type sequence R description BINDING SITE FOR RESIDUE PO4 C 303 source : AC9 46) chain D residue 129 type sequence A description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 47) chain D residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 48) chain D residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 49) chain D residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 50) chain D residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 51) chain D residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 52) chain D residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV D 301 source : BC2 53) chain D residue 221 type sequence R description BINDING SITE FOR RESIDUE PO4 D 302 source : BC3 54) chain A residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 55) chain C residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 56) chain C residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 57) chain C residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 58) chain D residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 59) chain D residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 60) chain D residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 61) chain D residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 69) chain C residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 70) chain A residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 71) chain A residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 72) chain B residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 73) chain B residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 74) chain C residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 75) chain C residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 76) chain D residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 77) chain D residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2

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