eF-site ID 3w67-ABCD PDB Code 3w67 Chain A, B, C, D click to enlarge Title Crystal structure of mouse alpha-tocopherol transfer protein in complex with alpha-tocopherol and phosphatidylinositol-(3,4)-bisphosphate Classification TRANSPORT PROTEIN Compound Alpha-tocopherol transfer protein Source Mus musculus (Mouse) (TTPA_MOUSE) Sequence A:  QPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLD LAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVL RSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIV QEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLT DSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHL HGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIM KSEDYLSSISE B:  LLQPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFD LDLAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHG VLRSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSEL IVQEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAV LTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRI HLHGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNF IMKSEDYLSSISE C:  PGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLDL AWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVLR SRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIVQ EVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLTD SFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLH GNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIMK SEDYLSSISE D:  QPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLD LAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVL RSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIV QEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLT DSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHL HGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIM KSEDYLSSISE Description Functional site 1) chain A residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 2) chain A residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 3) chain A residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV A 301 source : AC1 4) chain A residue 183 type sequence L description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 5) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 6) chain A residue 185 type sequence D description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 7) chain A residue 190 type sequence K description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 8) chain A residue 191 type sequence V description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 9) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 10) chain A residue 214 type sequence L description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 11) chain A residue 217 type sequence K description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 12) chain A residue 218 type sequence I description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 13) chain A residue 221 type sequence R description BINDING SITE FOR RESIDUE 3PT A 302 source : AC2 14) chain B residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 15) chain B residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 16) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 17) chain B residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 18) chain B residue 183 type sequence L description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 19) chain B residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV B 301 source : AC3 20) chain B residue 183 type sequence L description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 21) chain B residue 184 type sequence T description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 22) chain B residue 185 type sequence D description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 23) chain B residue 190 type sequence K description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 24) chain B residue 191 type sequence V description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 25) chain B residue 192 type sequence R description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 26) chain B residue 213 type sequence F description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 27) chain B residue 217 type sequence K description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 28) chain B residue 221 type sequence R description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 29) chain B residue 222 type sequence I description BINDING SITE FOR RESIDUE 3PT B 302 source : AC4 30) chain C residue 122 type sequence W description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 31) chain C residue 133 type sequence F description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 32) chain C residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 33) chain C residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 34) chain C residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 35) chain C residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 36) chain C residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 37) chain C residue 183 type sequence L description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 38) chain C residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV C 301 source : AC5 39) chain C residue 183 type sequence L description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 40) chain C residue 184 type sequence T description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 41) chain C residue 190 type sequence K description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 42) chain C residue 191 type sequence V description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 43) chain C residue 192 type sequence R description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 44) chain C residue 217 type sequence K description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 45) chain C residue 218 type sequence I description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 46) chain C residue 221 type sequence R description BINDING SITE FOR RESIDUE 3PT C 302 source : AC6 47) chain D residue 129 type sequence A description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 48) chain D residue 136 type sequence S description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 49) chain D residue 137 type sequence L description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 50) chain D residue 140 type sequence S description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 51) chain D residue 158 type sequence F description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 52) chain D residue 182 type sequence V description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 53) chain D residue 183 type sequence L description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 54) chain D residue 187 type sequence F description BINDING SITE FOR RESIDUE VIV D 301 source : AC7 55) chain D residue 183 type sequence L description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 56) chain D residue 184 type sequence T description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 57) chain D residue 190 type sequence K description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 58) chain D residue 191 type sequence V description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 59) chain D residue 192 type sequence R description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 60) chain D residue 213 type sequence F description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 61) chain D residue 218 type sequence I description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 62) chain D residue 221 type sequence R description BINDING SITE FOR RESIDUE 3PT D 302 source : AC8 63) chain A residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 64) chain C residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 65) chain C residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 66) chain C residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 67) chain D residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 68) chain D residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 69) chain D residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 70) chain D residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 71) chain A residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 72) chain A residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 73) chain A residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 190 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 217 type BINDING sequence K description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 221 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 78) chain C residue 185 type BINDING sequence D description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W67 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 80) chain A residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 81) chain B residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 82) chain B residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 83) chain C residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 84) chain C residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 85) chain D residue 187 type BINDING sequence F description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2 86) chain D residue 208 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23599266, ECO:0007744|PDB:3W68 source Swiss-Prot : SWS_FT_FI2

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