|
eF-site ID
|
3w13-ABCDEF |
PDB Code
|
3w13 |
Chain
|
A, B, C, D, E, F |
|
click to enlarge
|
|
Title
|
Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity insulin analogue [D-PRO-B26]-DTI-NH2, alphact peptide(693-719) and FAB 83-7 |
Classification
|
HORMONE RECEPTOR/HORMONE/IMMUNE SYSTEM |
Compound
|
Insulin receptor domains L1-CR |
Source
|
(3W13) |
|
Sequence
|
A: |
GIVEQCCTSICSLYQLENYCN
|
B: |
CGSHLVEALYLVCGE
|
C: |
QVQLKESGPGLVAPSQSLSITCTVSGFPLTAYGVNWVRQP
PGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFL
KMNSLQTDDTARYYCARDPYGSKPMDYWGQGTSVTV
|
D: |
DIVMSQSPSSLVVSVGEKVTMSCKSSQSLLYSSNQKNFLA
WYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLT
ISSVKAEDLAVYYCQQYFRYRTFGGGTKLEIKRA
|
E: |
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE
DFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRG
SRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNE
LCYLATIDWSRILDSVEDNHIVLNKDDNEECGDICNCPAT
VINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWR
CVNFSFCQDLHHKQYVIHNNKCIPECPSGYTMNSSNLLCT
PCLGPCPK
|
F: |
FEDYLHNVVFV
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
6-20 |
type |
prosite |
sequence |
CCTSICSLYQLENYC
|
description |
INSULIN Insulin family signature. CCTSiCSlyqLenyC
|
source |
prosite : PS00262
|
|
2)
|
chain |
E |
residue |
39 |
type |
SITE |
sequence |
F
|
description |
Insulin-binding => ECO:0000305
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
E |
residue |
16 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
E |
residue |
25 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
E |
residue |
111 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
E |
residue |
255 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
E |
residue |
78 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
8)
|
chain |
E |
residue |
295 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
9)
|
chain |
E |
residue |
215 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|