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eF-site ID
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3w11-ABCDEF |
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PDB Code
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3w11 |
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Chain
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A, B, C, D, E, F |
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click to enlarge
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Title
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Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin, Alpha-CT peptide(704-719) and FAB 83-7 |
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Classification
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HORMONE/HORMONE RECEPTOR/IMMUNE SYSTEM |
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Compound
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Insulin A chain |
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Source
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(3W11) |
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Sequence
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A: |
GIVEQCCTSICSLYQLENYCN
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| B: |
CGSHLVEALYLVCGE
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| C: |
QVQLKESGPGLVAPSQSLSITCTVSGFPLTAYGVNWVRQP
PGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFL
KMNSLQTDDTARYYCARDPYGSKPMDYWGQGTSVTVSS
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| D: |
DIVMSQSPSSLVVSVGEKVTMSCKSSQSLLYSSNQKNFLA
WYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLT
ISSVKAEDLAVYYCQQYFRYRTFGGGTKLEIKRA
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| E: |
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE
DFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRG
SRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNE
LCYLATIDWSRILDSVEDNHIVLNKDDNEECGDICNCPAT
VINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSEC
LGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWR
CVNFSFCQDLHHKQYVIHNNKCIPECPSGYTMNSSNLLCT
PCLGPCPK
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| F: |
FEDYLHNVVFV
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Description
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Functional site
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1)
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chain |
A |
| residue |
6-20 |
| type |
prosite |
| sequence |
CCTSICSLYQLENYC
|
| description |
INSULIN Insulin family signature. CCTSiCSlyqLenyC
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| source |
prosite : PS00262
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2)
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chain |
E |
| residue |
39 |
| type |
SITE |
| sequence |
F
|
| description |
Insulin-binding => ECO:0000305
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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3)
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chain |
E |
| residue |
16 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222
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| source |
Swiss-Prot : SWS_FT_FI2
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|
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4)
|
chain |
E |
| residue |
25 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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5)
|
chain |
E |
| residue |
111 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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6)
|
chain |
E |
| residue |
255 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862
|
| source |
Swiss-Prot : SWS_FT_FI3
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7)
|
chain |
E |
| residue |
78 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI4
|
|
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8)
|
chain |
E |
| residue |
295 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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9)
|
chain |
E |
| residue |
215 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862
|
| source |
Swiss-Prot : SWS_FT_FI5
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