eF-site ID 3w0p-A
PDB Code 3w0p
Chain A

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Title Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (D198A), ternary complex with ADP and hygromycin B
Classification TRANSFERASE/ANTIBIOTIC
Compound Hygromycin-B 4-O-kinase
Source Escherichia coli (KHYB_ECOLX)
Sequence A:  TSVEKFLIEKFGSVSDLMQLSEGEESRAFSFDVGGRGYVL
RVNSCADGFYKDRYVYRHFASAALPIPEVLDIGEFSESLT
YCISRRAQGVTLQDLPETELPAVLQPVAEVMDAIAAADLS
QTSGFGPFGPQGIGQYTTWRDFICAIADPHVYHWQTVMDD
TVSASVAQALDELMLWAEDCPEVRHLVHAAFGSNNVLTDN
GRITAVIDWSEAMFGDPLYEVANIFFWRPWLACMEQQARY
FERRHPELAGSPRLRAYMLRIGLDQLYQSLVDGNFDDAAW
AQGRCDAIVRSGAGT
Description


Functional site

1) chain A
residue 28
type
sequence L
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

2) chain A
residue 29
type
sequence S
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

3) chain A
residue 36
type
sequence A
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

4) chain A
residue 47
type
sequence V
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

5) chain A
residue 75
type
sequence P
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

6) chain A
residue 93
type
sequence R
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

7) chain A
residue 94
type
sequence R
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

8) chain A
residue 95
type
sequence A
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

9) chain A
residue 99
type
sequence T
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

10) chain A
residue 205
type
sequence L
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

11) chain A
residue 215
type
sequence I
description BINDING SITE FOR RESIDUE ADP A 401
source : AC1

12) chain A
residue 101
type
sequence Q
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

13) chain A
residue 126
type
sequence D
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

14) chain A
residue 198
type
sequence A
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

15) chain A
residue 201
type
sequence S
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

16) chain A
residue 202
type
sequence N
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

17) chain A
residue 231
type
sequence N
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

18) chain A
residue 235
type
sequence W
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

19) chain A
residue 238
type
sequence W
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

20) chain A
residue 239
type
sequence L
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

21) chain A
residue 273
type
sequence Q
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

22) chain A
residue 285
type
sequence D
description BINDING SITE FOR RESIDUE HY0 A 402
source : AC2

23) chain A
residue 198
type ACT_SITE
sequence A
description Proton acceptor => ECO:0000250
source Swiss-Prot : SWS_FT_FI1


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