eF-site ID 3vw7-A PDB Code 3vw7 Chain A click to enlarge Title Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom Classification Signaling protein/antagonist Compound Proteinase-activated receptor 1, Lysozyme Source Homo sapiens (Human) (PAR1_HUMAN) Sequence A:  DASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILK MKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQF GSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMRT LGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLGITTCH DVLSETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIR CLSSSANIFEMLRIDEGLRLKIYKNTEGYYTIGIGHLLTK SPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAV RGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFT NSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRT GTWDAYANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAH YSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASS EC Description Functional site 1) chain A residue 183 type sequence Y description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 2) chain A residue 187 type sequence Y description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 3) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 4) chain A residue 255 type sequence H description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 5) chain A residue 256 type sequence D description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 6) chain A residue 257 type sequence V description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 7) chain A residue 258 type sequence L description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 8) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 9) chain A residue 1080 type sequence R description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 10) chain A residue 332 type sequence L description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 11) chain A residue 333 type sequence L description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 12) chain A residue 337 type sequence Y description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 13) chain A residue 349 type sequence A description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 14) chain A residue 350 type sequence Y description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 15) chain A residue 353 type sequence Y description BINDING SITE FOR RESIDUE VPX A 2001 source : AC1 16) chain A residue 157 type sequence F description BINDING SITE FOR RESIDUE OLC A 2002 source : AC2 17) chain A residue 206 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2002 source : AC2 18) chain A residue 284 type sequence I description BINDING SITE FOR RESIDUE OLC A 2002 source : AC2 19) chain A residue 295 type sequence R description BINDING SITE FOR RESIDUE OLC A 2002 source : AC2 20) chain A residue 160 type sequence S description BINDING SITE FOR RESIDUE OLC A 2003 source : AC3 21) chain A residue 164 type sequence S description BINDING SITE FOR RESIDUE OLC A 2003 source : AC3 22) chain A residue 113 type sequence F description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 23) chain A residue 156 type sequence P description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 24) chain A residue 160 type sequence S description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 25) chain A residue 163 type sequence F description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 26) chain A residue 164 type sequence S description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 27) chain A residue 202 type sequence L description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 28) chain A residue 229 type sequence L description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 29) chain A residue 278 type sequence F description BINDING SITE FOR RESIDUE OLC A 2004 source : AC4 30) chain A residue 122 type sequence M description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 31) chain A residue 126 type sequence V description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 32) chain A residue 127 type sequence F description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 33) chain A residue 365 type sequence C description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 34) chain A residue 368 type sequence P description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 35) chain A residue 371 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 36) chain A residue 372 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 37) chain A residue 375 type sequence S description BINDING SITE FOR RESIDUE OLC A 2005 source : AC5 38) chain A residue 100 type sequence W description BINDING SITE FOR RESIDUE OLC A 2006 source : AC6 39) chain A residue 328 type sequence P description BINDING SITE FOR RESIDUE OLC A 2006 source : AC6 40) chain A residue 348 type sequence A description BINDING SITE FOR RESIDUE OLC A 2006 source : AC6 41) chain A residue 351 type sequence F description BINDING SITE FOR RESIDUE OLC A 2006 source : AC6 42) chain A residue 356 type sequence C description BINDING SITE FOR RESIDUE OLC A 2006 source : AC6 43) chain A residue 327 type sequence G description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 44) chain A residue 328 type sequence P description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 45) chain A residue 343 type sequence T description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 46) chain A residue 346 type sequence T description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 47) chain A residue 348 type sequence A description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 48) chain A residue 356 type sequence C description BINDING SITE FOR RESIDUE OLC A 2007 source : AC7 49) chain A residue 139 type sequence V description BINDING SITE FOR RESIDUE OLC A 2008 source : AC8 50) chain A residue 143 type sequence H description BINDING SITE FOR RESIDUE OLC A 2008 source : AC8 51) chain A residue 220 type sequence S description BINDING SITE FOR RESIDUE OLC A 2008 source : AC8 52) chain A residue 224 type sequence L description BINDING SITE FOR RESIDUE OLC A 2008 source : AC8 53) chain A residue 228 type sequence A description BINDING SITE FOR RESIDUE OLC A 2008 source : AC8 54) chain A residue 236 type sequence P description BINDING SITE FOR RESIDUE OLC A 2009 source : AC9 55) chain A residue 240 type sequence K description BINDING SITE FOR RESIDUE OLC A 2009 source : AC9 56) chain A residue 270 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2009 source : AC9 57) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE OLC A 2009 source : AC9 58) chain A residue 163 type sequence F description BINDING SITE FOR RESIDUE OLC A 2010 source : BC1 59) chain A residue 221 type sequence F description BINDING SITE FOR RESIDUE OLC A 2010 source : BC1 60) chain A residue 222 type sequence T description BINDING SITE FOR RESIDUE OLC A 2010 source : BC1 61) chain A residue 135 type sequence K description BINDING SITE FOR RESIDUE CL A 2011 source : BC2 62) chain A residue 307 type sequence K description BINDING SITE FOR RESIDUE CL A 2011 source : BC2 63) chain A residue 144 type sequence L description BINDING SITE FOR RESIDUE NA A 2012 source : BC3 64) chain A residue 148 type sequence D description BINDING SITE FOR RESIDUE NA A 2012 source : BC3 65) chain A residue 189 type sequence S description BINDING SITE FOR RESIDUE NA A 2012 source : BC3 66) chain A residue 367 type sequence D description BINDING SITE FOR RESIDUE NA A 2012 source : BC3 67) chain A residue 1011 type catalytic sequence E description 921 source MCSA : MCSA1 68) chain A residue 1020 type catalytic sequence N description 921 source MCSA : MCSA1 69) chain A residue 250 type CARBOHYD sequence G description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10 70) chain A residue 259 type CARBOHYD sequence S description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI10 71) chain A residue 1117 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI14 72) chain A residue 1132 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI14 73) chain A residue 1011 type ACT_SITE sequence E description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI11 74) chain A residue 1020 type ACT_SITE sequence N description Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI12 75) chain A residue 312-334 type TRANSMEM sequence LFLSAAVFCIFIICFGPTNVLLI description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 76) chain A residue 1032 type BINDING sequence L description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI13 77) chain A residue 1104 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI13 78) chain A residue 351-374 type TRANSMEM sequence FAYLLCVCVSSISCCIDPLIYYYA description Helical; Name=7 => ECO:0000255 source Swiss-Prot : SWS_FT_FI9 79) chain A residue 103-128 type TRANSMEM sequence LFVPSVYTGVFVVSLPLNIMAIVVFI description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 80) chain A residue 129-137 type TOPO_DOM sequence LKMKVKKPA description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 81) chain A residue 199-218 type TOPO_DOM sequence DRFLAVVYPMRTLGR description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 82) chain A residue 138-157 type TRANSMEM sequence VVYMLHLATADVLFVSVLPF description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 83) chain A residue 158-176 type TOPO_DOM sequence KISYYFSGSDWQFGSELCR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 84) chain A residue 240-268 type TOPO_DOM sequence KEQTIQVPGLGITTCHDVLSETLLEGYYA description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 85) chain A residue 335-350 type TOPO_DOM sequence AHYSFLSHTSTTEAAY description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 86) chain A residue 177-198 type TRANSMEM sequence FVTAAFYCNMYASILLMTVISI description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 87) chain A residue 219-239 type TRANSMEM sequence ASFTCLAIWALAIAGVVPLLL description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 88) chain A residue 269-288 type TRANSMEM sequence YYFSAFSAVFFFVPLIISTV description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 89) chain A residue 188-204 type prosite sequence ASILLMTVISIDRFLAV description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLMTVISIDRFLaV source prosite : PS00237

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