eF-site ID 3vuh-A PDB Code 3vuh Chain A click to enlarge Title Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Mitogen-activated protein kinase 8 Source (JIP1_HUMAN) Sequence A:  DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA ILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII GLLNVFTPQKSLEEFQDVYIVMELMDANLSQVIQMELDHE RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDATLK ILDFGLARTAGTSTPYVVTRYYRAPEVILGMGYKENVDIW SVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPSPEFM KKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKL KASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSE AEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE Description Functional site 1) chain A residue 189 type sequence R description BINDING SITE FOR RESIDUE SO4 A 400 source : AC1 2) chain A residue 192 type sequence R description BINDING SITE FOR RESIDUE SO4 A 400 source : AC1 3) chain A residue 230 type sequence H description BINDING SITE FOR RESIDUE SO4 A 400 source : AC1 4) chain A residue 255 type sequence T description BINDING SITE FOR RESIDUE SO4 A 400 source : AC1 5) chain A residue 153 type sequence K description BINDING SITE FOR RESIDUE SO4 A 401 source : AC2 6) chain A residue 155 type sequence S description BINDING SITE FOR RESIDUE SO4 A 401 source : AC2 7) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 A 402 source : AC3 8) chain A residue 263 type sequence R description BINDING SITE FOR RESIDUE SO4 A 402 source : AC3 9) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC4 10) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC4 11) chain A residue 150 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC4 12) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC4 13) chain A residue 183 type sequence T description BINDING SITE FOR RESIDUE SO4 A 403 source : AC4 14) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE SO4 A 404 source : AC5 15) chain A residue 56 type sequence K description BINDING SITE FOR RESIDUE SO4 A 404 source : AC5 16) chain A residue 57 type sequence L description BINDING SITE FOR RESIDUE SO4 A 404 source : AC5 17) chain A residue 58 type sequence S description BINDING SITE FOR RESIDUE SO4 A 404 source : AC5 18) chain A residue 66 type sequence H description BINDING SITE FOR RESIDUE SO4 A 404 source : AC5 19) chain A residue 109 type sequence E description BINDING SITE FOR RESIDUE GOL A 405 source : AC6 20) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE GOL A 405 source : AC6 21) chain A residue 111 type sequence M description BINDING SITE FOR RESIDUE GOL A 405 source : AC6 22) chain A residue 15 type sequence I description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 23) chain A residue 17 type sequence D description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 24) chain A residue 31 type sequence P description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 25) chain A residue 33 type sequence G description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 26) chain A residue 34 type sequence S description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 27) chain A residue 39 type sequence I description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 28) chain A residue 40 type sequence V description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 29) chain A residue 121 type sequence M description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 30) chain A residue 127 type sequence R description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 31) chain A residue 130 type sequence Y description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 32) chain A residue 161 type sequence S description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 33) chain A residue 162 type sequence D description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 34) chain A residue 163 type sequence A description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 35) chain A residue 324 type sequence W description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 36) chain A residue 329 type sequence E description BINDING SITE FOR CHAIN F OF PEPTIDE FROM C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 source : AC7 37) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 38) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 40) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 116 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3 42) chain A residue 183 type MOD_RES sequence T description Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI4 43) chain A residue 185 type MOD_RES sequence Y description Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067 source Swiss-Prot : SWS_FT_FI5

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