eF-site ID 3vsx-A
PDB Code 3vsx
Chain A

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Title Human renin in complex with compound 18
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Renin
Source null (RENI_HUMAN)
Sequence A:  LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTG
SSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELT
LRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFM
LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSF
YYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGV
WQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE
KLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLT
SADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFI
RKFYTEFDRRNNRIGFALAR
Description


Functional site
1) chain A
residue 35-46
type prosite
sequence VVFDTGSSNVWV
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
source prosite : PS00141
2) chain A
residue 223-234
type prosite
sequence ALVDTGASYISG
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VVFDTGSSNVWV
source prosite : PS00141
3) chain A
residue 38
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000269|PubMed:20927107
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 226
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000269|PubMed:20927107
source Swiss-Prot : SWS_FT_FI1
5) chain A
residue 5
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
source Swiss-Prot : SWS_FT_FI2
6) chain A
residue 75
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2493678
source Swiss-Prot : SWS_FT_FI2

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