eF-site ID 3vi8-A PDB Code 3vi8 Chain A click to enlarge Title Human PPAR alpha ligand binding domain in complex with a synthetic agonist APHM13 Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor alpha Source Homo sapiens (Human) (PPARA_HUMAN) Sequence A:  DLKSLAKRIYEAYLKNFNMNKVKARVILSPFVIHDMETLC MAEKTLVAKLVANGNKEAEVRIFHCCQCTSVETVTELTEF AKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGM LVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALEL DDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRL HLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKT ESDAALHPLLQEIYRDMY Description Functional site 1) chain A residue 273 type sequence F description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 2) chain A residue 276 type sequence C description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 3) chain A residue 279 type sequence T description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 4) chain A residue 280 type sequence S description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 5) chain A residue 314 type sequence Y description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 6) chain A residue 330 type sequence M description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 7) chain A residue 332 type sequence V description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 8) chain A residue 333 type sequence A description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 9) chain A residue 339 type sequence I description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 10) chain A residue 355 type sequence M description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 11) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 12) chain A residue 460 type sequence L description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 13) chain A residue 464 type sequence Y description BINDING SITE FOR RESIDUE 13M A 1 source : AC1 14) chain A residue 280 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 314 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 464 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 433 type SITE sequence L description Essential for heterodimerization with RXRA source Swiss-Prot : SWS_FT_FI2

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