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|
eF-site ID
|
3v4v-D |
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PDB Code
|
3v4v |
|
Chain
|
D |
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click to enlarge
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Title
|
crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 |
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Classification
|
CELL ADHESION |
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Compound
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Integrin alpha-4 |
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Source
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(3V4V) |
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Sequence
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D: |
RGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQ
LQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALL
VRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTR
LERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPE
GGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGK
LGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSA
ANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVV
QLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKRE
GKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRA
LGFSEELIVELHTLC
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Description
|
(1) |
Integrin alpha-4, Integrin beta-7, heavy chain, light chain
|
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Functional site
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|
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1)
|
chain |
D |
| residue |
415 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
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2)
|
chain |
D |
| residue |
240 |
| type |
BINDING |
| sequence |
E
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
D |
| residue |
270 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site and liganded-open conformation => ECO:0000250|UniProtKB:P05107
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
D |
| residue |
354 |
| type |
BINDING |
| sequence |
E
|
| description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
5)
|
chain |
D |
| residue |
260 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
6)
|
chain |
D |
| residue |
142 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
D |
| residue |
144 |
| type |
BINDING |
| sequence |
S
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
D |
| residue |
147 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
D |
| residue |
235 |
| type |
BINDING |
| sequence |
N
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
10)
|
chain |
D |
| residue |
237 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
11)
|
chain |
D |
| residue |
239 |
| type |
BINDING |
| sequence |
P
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
D |
| residue |
179 |
| type |
BINDING |
| sequence |
D
|
| description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
13)
|
chain |
D |
| residue |
148 |
| type |
BINDING |
| sequence |
D
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|