|
eF-site ID
|
3v4v-B |
PDB Code
|
3v4v |
Chain
|
B |
|
click to enlarge
|
|
Title
|
crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 |
Classification
|
CELL ADHESION |
Compound
|
Integrin alpha-4 |
Source
|
(3V4V) |
|
Sequence
|
B: |
RGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQ
LQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALL
VRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTR
LERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPE
GGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGK
LGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSA
ANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVV
QLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKRE
GKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRA
LGFSEELIVELHTLC
|
|
Description
|
(1) |
Integrin alpha-4, Integrin beta-7, heavy chain, light chain
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
142 |
type |
BINDING |
sequence |
S
|
description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
144 |
type |
BINDING |
sequence |
S
|
description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
B |
residue |
415 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI10
|
|
4)
|
chain |
B |
residue |
147 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
B |
residue |
148 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
6)
|
chain |
B |
residue |
179 |
type |
BINDING |
sequence |
D
|
description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
7)
|
chain |
B |
residue |
235 |
type |
BINDING |
sequence |
N
|
description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
8)
|
chain |
B |
residue |
237 |
type |
BINDING |
sequence |
D
|
description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
9)
|
chain |
B |
residue |
239 |
type |
BINDING |
sequence |
P
|
description |
in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
10)
|
chain |
B |
residue |
240 |
type |
BINDING |
sequence |
E
|
description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI5
|
|
11)
|
chain |
B |
residue |
270 |
type |
BINDING |
sequence |
D
|
description |
in ADMIDAS binding site and liganded-open conformation => ECO:0000250|UniProtKB:P05107
|
source |
Swiss-Prot : SWS_FT_FI6
|
|
12)
|
chain |
B |
residue |
354 |
type |
BINDING |
sequence |
E
|
description |
in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI7
|
|
13)
|
chain |
B |
residue |
260 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V
|
source |
Swiss-Prot : SWS_FT_FI9
|
|
|
|