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eF-site ID
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3v4p-A |
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PDB Code
|
3v4p |
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Chain
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A |
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click to enlarge
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Title
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crystal structure of a4b7 headpiece complexed with Fab ACT-1 |
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Classification
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CELL ADHESION |
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Compound
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Integrin alpha-4 |
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Source
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(3V4P) |
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Sequence
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A: |
YNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPT
ANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEP
CGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFY
IKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGE
NFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTN
KYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAP
QHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAV
DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNA
METNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQE
DDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQS
ISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASL
SHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYI
VLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSR
EANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHSTEEFPP
LQPILQQKKEKDIMKKTINFAR
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Description
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(1) |
Integrin alpha-4, Integrin beta-7, heavy chain, light chain
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Functional site
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1)
|
chain |
A |
| residue |
408 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
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| source |
Swiss-Prot : SWS_FT_FI1
|
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2)
|
chain |
A |
| residue |
410 |
| type |
BINDING |
| sequence |
N
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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3)
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chain |
A |
| residue |
412 |
| type |
BINDING |
| sequence |
Y
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
A |
| residue |
414 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
344 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
346 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
348 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
352 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
406 |
| type |
BINDING |
| sequence |
D
|
| description |
in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
A |
| residue |
196 |
| type |
BINDING |
| sequence |
N
|
| description |
in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P
|
| source |
Swiss-Prot : SWS_FT_FI3
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