eF-site ID 3v00-B PDB Code 3v00 Chain B click to enlarge Title Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation. Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(t) subunit alpha-1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 chimeric protein Source Bos taurus (Bovine) (GNAT1_BOVIN) Sequence B:  EKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQ MKIIHQDPYSLEECLEFIAIIYGNTLQSILAIVRAMTTLN IQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWK DSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQ DVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWI HCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMHLFNS ICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAG SNTYEEAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNV KFVFDAVTDIIIKENLKDCGLF Description Functional site 1) chain B residue 37 type sequence A description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 2) chain B residue 38 type sequence G description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 3) chain B residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 4) chain B residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 5) chain B residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 6) chain B residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 7) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 8) chain B residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 9) chain B residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 10) chain B residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 11) chain B residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 12) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 13) chain B residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 14) chain B residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 15) chain B residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 16) chain B residue 269 type sequence L description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 17) chain B residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 18) chain B residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 19) chain B residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP B 401 source : AC2 20) chain B residue 265 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI6 21) chain B residue 142 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI4 22) chain B residue 43 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 177 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 36 type BINDING sequence G description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 171 type BINDING sequence L description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 199 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 28) chain B residue 322 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3

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