eF-site ID 3v00-A PDB Code 3v00 Chain A click to enlarge Title Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation. Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(t) subunit alpha-1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 chimeric protein Source Bos taurus (Bovine) (GNAT1_BOVIN) Sequence A:  HMGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGE SGKSTIVKQMKIIHQDPYSLEECLEFIAIIYGNTLQSILA IVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEM SDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLV TPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGG QRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRM HESMHLFNSICNNKWFTDTSIILFLNKKDLFEEKIKKSPL TICYPEYAGSNTYEEAGNYIKVQFLELNMRRDVKEIYSHM TCATDTQNVKFVFDAVTDIIIKENLKDCGLF Description Functional site 1) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 2) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 3) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 4) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 5) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 6) chain A residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 7) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 8) chain A residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 9) chain A residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 10) chain A residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 11) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 12) chain A residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 13) chain A residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 14) chain A residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 15) chain A residue 269 type sequence L description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 16) chain A residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 17) chain A residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 18) chain A residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP A 401 source : AC3 19) chain A residue 36 type BINDING sequence G description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 146 type BINDING sequence D description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 171 type BINDING sequence L description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 43 type BINDING sequence S description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 177 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 199 type BINDING sequence G description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 25) chain A residue 322 type BINDING sequence A description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 26) chain A residue 142 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI4 27) chain A residue 2 type LIPID sequence G description N-myristoyl glycine => ECO:0000269|PubMed:1436039 source Swiss-Prot : SWS_FT_FI5 28) chain A residue 265 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI6

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