eF-site ID 3uzs-ABCG PDB Code 3uzs Chain A, B, C, G click to enlarge Title Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex Classification TRANSFERASE/RNA Compound Beta-adrenergic receptor kinase 1 Source null (3UZS) Sequence A:  SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLF RDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREI FDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQP YIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTM NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH SPVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVK ESPFFRSLDWQMVFLQKYPPPLIPPRGEEDTKGIKLLDSD QELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKT KNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFY LFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLL KIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVP KMKNKPRAP B:  SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVG RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLII WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS GRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT DDGMAVATGSWDSFLKIWN C:  GGCAGACCAUACGGGUUGCC G:  ASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYC EAHAKEDPLLTPVPASENPFREKKFFX Description Functional site 1) chain A residue 335 type sequence D description BINDING SITE FOR RESIDUE MG A 701 source : AC1 2) chain C residue 50 type sequence U description BINDING SITE FOR RESIDUE MG A 701 source : AC1 3) chain B residue 70-84 type prosite sequence LVSASQDGKLIIWDS description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 4) chain B residue 157-171 type prosite sequence IVTSSGDTTCALWDI description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 5) chain B residue 285-299 type prosite sequence LLAGYDDFNCNVWDA description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 6) chain G residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|PubMed:7626050 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 220 type MOD_RES sequence K description Phosphohistidine => ECO:0000269|PubMed:12486123 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 266 type MOD_RES sequence H description Phosphohistidine => ECO:0000269|PubMed:12486123 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 670 type MOD_RES sequence A description Phosphoserine => ECO:0000250|UniProtKB:P25098 source Swiss-Prot : SWS_FT_FI4 10) chain A residue 197-220 type prosite sequence IGRGGFGEVYGCRKADTGKMYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK source prosite : PS00107 11) chain A residue 313-325 type prosite sequence VVYRDLKPANILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL source prosite : PS00108

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