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eF-site ID
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3uzs-A |
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PDB Code
|
3uzs |
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Chain
|
A |
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click to enlarge
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Title
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Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex |
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Classification
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TRANSFERASE/RNA |
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Compound
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Beta-adrenergic receptor kinase 1 |
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Source
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Bos taurus (Bovine) (3UZS) |
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Sequence
|
A: |
SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLF
RDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREI
FDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQP
YIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTM
NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK
MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS
FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHM
HNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH
ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH
SPVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVK
ESPFFRSLDWQMVFLQKYPPPLIPPRGEEDTKGIKLLDSD
QELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKT
KNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFY
LFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLL
KIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVP
KMKNKPRAP
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Description
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Functional site
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|
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1)
|
chain |
A |
| residue |
335 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG A 701
|
| source |
: AC1
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|
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2)
|
chain |
A |
| residue |
670 |
| type |
MOD_RES |
| sequence |
A
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P25098
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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3)
|
chain |
A |
| residue |
220 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphohistidine => ECO:0000269|PubMed:12486123
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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4)
|
chain |
A |
| residue |
197-220 |
| type |
prosite |
| sequence |
IGRGGFGEVYGCRKADTGKMYAMK
|
| description |
PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK
|
| source |
prosite : PS00107
|
|
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5)
|
chain |
A |
| residue |
313-325 |
| type |
prosite |
| sequence |
VVYRDLKPANILL
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL
|
| source |
prosite : PS00108
|
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