eF-site ID 3uvo-AB PDB Code 3uvo Chain A, B click to enlarge Title Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B Classification TRANSCRIPTION Compound WD repeat-containing protein 5 Source Homo sapiens (Human) (SET1B_HUMAN) Sequence A:  VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS YDGLCRIWDTASGQCLKTLIPPVSFVKFSPNGKYILAATL DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN IIASAALENDKTIKLWKSDC B:  CARSEGFYT Description Functional site 1) chain A residue 112 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 46 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI3 3) chain A residue 107 type SITE sequence D description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 133 type SITE sequence F description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 263 type SITE sequence F description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 322 type SITE sequence E description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 102-116 type prosite sequence LVSASDDKTLKIWDV description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV source prosite : PS00678 8) chain A residue 144-158 type prosite sequence IVSGSFDESVRIWDV description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV source prosite : PS00678 9) chain A residue 186-200 type prosite sequence IVSSSYDGLCRIWDT description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV source prosite : PS00678 10) chain A residue 274-288 type prosite sequence IVSGSEDNLVYIWNL description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV source prosite : PS00678

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