eF-site ID 3ur4-B PDB Code 3ur4 Chain B click to enlarge Title Crystal structure of human WD repeat domain 5 with compound Classification TRANSCRIPTION/INHIBITOR Compound WD repeat-containing protein 5 Source null (WDR5_HUMAN) Sequence B:  VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS YDGLCRIWDTASGQCLKTLINPPVSFVKFSPNGKYILAAT LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE NIIASAALENDKTIKLWKSDC Description Functional site 1) chain B residue 117 type sequence S description BINDING SITE FOR RESIDUE SO4 A 3002 source : AC9 2) chain B residue 49 type sequence S description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 3) chain B residue 50 type sequence S description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 4) chain B residue 65 type sequence A description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 5) chain B residue 89 type sequence G description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 6) chain B residue 90 type sequence I description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 7) chain B residue 91 type sequence S description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 8) chain B residue 92 type sequence D description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 9) chain B residue 133 type sequence F description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 10) chain B residue 175 type sequence S description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 11) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 12) chain B residue 261 type sequence C description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 13) chain B residue 305 type sequence I description BINDING SITE FOR RESIDUE 0BW B 1000 source : BC1 14) chain B residue 98 type sequence D description BINDING SITE FOR RESIDUE EDO B 2001 source : BC2 15) chain B residue 100 type sequence N description BINDING SITE FOR RESIDUE EDO B 2001 source : BC2 16) chain B residue 101 type sequence L description BINDING SITE FOR RESIDUE EDO B 2001 source : BC2 17) chain B residue 228 type sequence Y description BINDING SITE FOR RESIDUE EDO B 2002 source : BC3 18) chain B residue 250 type sequence K description BINDING SITE FOR RESIDUE EDO B 2002 source : BC3 19) chain B residue 289 type sequence Q description BINDING SITE FOR RESIDUE EDO B 2002 source : BC3 20) chain B residue 272 type sequence K description BINDING SITE FOR RESIDUE EDO B 2008 source : BC4 21) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE EDO B 2009 source : BC5 22) chain B residue 234 type sequence L description BINDING SITE FOR RESIDUE EDO B 2009 source : BC5 23) chain B residue 259 type sequence K description BINDING SITE FOR RESIDUE EDO B 2009 source : BC5 24) chain B residue 165 type sequence K description BINDING SITE FOR RESIDUE EDO B 2010 source : BC6 25) chain B residue 200 type sequence T description BINDING SITE FOR RESIDUE EDO B 2010 source : BC6 26) chain B residue 201 type sequence A description BINDING SITE FOR RESIDUE EDO B 2010 source : BC6 27) chain B residue 191 type sequence Y description BINDING SITE FOR RESIDUE EDO B 2014 source : BC7 28) chain B residue 97 type sequence S description BINDING SITE FOR RESIDUE CL B 335 source : BC8 29) chain B residue 98 type sequence D description BINDING SITE FOR RESIDUE CL B 335 source : BC8 30) chain B residue 141 type sequence S description BINDING SITE FOR RESIDUE CL B 335 source : BC8 31) chain B residue 52 type sequence K description BINDING SITE FOR RESIDUE CL B 1004 source : BC9 32) chain B residue 92 type sequence D description BINDING SITE FOR RESIDUE CL B 1004 source : BC9 33) chain B residue 135 type sequence C description BINDING SITE FOR RESIDUE CL B 1004 source : BC9 34) chain B residue 136 type sequence N description BINDING SITE FOR RESIDUE CL B 1004 source : BC9 35) chain B residue 52 type sequence K description BINDING SITE FOR RESIDUE SO4 B 3001 source : CC1 36) chain B residue 178 type sequence H description BINDING SITE FOR RESIDUE SO4 B 3001 source : CC1 37) chain B residue 221 type sequence K description BINDING SITE FOR RESIDUE SO4 B 3001 source : CC1 38) chain B residue 263 type sequence F description BINDING SITE FOR RESIDUE SO4 B 3001 source : CC1 39) chain B residue 112 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 46 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI3 41) chain B residue 107 type SITE sequence D description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 133 type SITE sequence F description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 263 type SITE sequence F description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 322 type SITE sequence E description Important for interaction with histone H3 source Swiss-Prot : SWS_FT_FI1

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