eF-site ID 3ur4-A
PDB Code 3ur4
Chain A

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Title Crystal structure of human WD repeat domain 5 with compound
Classification TRANSCRIPTION/INHIBITOR
Compound WD repeat-containing protein 5
Source Homo sapiens (Human) (WDR5_HUMAN)
Sequence A:  VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK
IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT
LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD
ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS
YDGLCRIWDTASGQCLKTLIDDNPPVSFVKFSPNGKYILA
ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG
KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP
TENIIASAALENDKTIKLWKSDC
Description


Functional site

1) chain A
residue 49
type
sequence S
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

2) chain A
residue 50
type
sequence S
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

3) chain A
residue 65
type
sequence A
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

4) chain A
residue 89
type
sequence G
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

5) chain A
residue 90
type
sequence I
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

6) chain A
residue 91
type
sequence S
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

7) chain A
residue 133
type
sequence F
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

8) chain A
residue 175
type
sequence S
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

9) chain A
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

10) chain A
residue 261
type
sequence C
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

11) chain A
residue 305
type
sequence I
description BINDING SITE FOR RESIDUE 0BW A 1000
source : AC1

12) chain A
residue 228
type
sequence Y
description BINDING SITE FOR RESIDUE EDO A 2000
source : AC2

13) chain A
residue 250
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 2000
source : AC2

14) chain A
residue 289
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 2000
source : AC2

15) chain A
residue 191
type
sequence Y
description BINDING SITE FOR RESIDUE EDO A 2006
source : AC3

16) chain A
residue 223
type
sequence S
description BINDING SITE FOR RESIDUE CL A 1001
source : AC4

17) chain A
residue 224
type
sequence P
description BINDING SITE FOR RESIDUE CL A 1001
source : AC4

18) chain A
residue 225
type
sequence N
description BINDING SITE FOR RESIDUE CL A 1001
source : AC4

19) chain A
residue 221
type
sequence K
description BINDING SITE FOR RESIDUE CL A 1002
source : AC5

20) chain A
residue 265
type
sequence N
description BINDING SITE FOR RESIDUE CL A 1002
source : AC5

21) chain A
residue 309
type
sequence C
description BINDING SITE FOR RESIDUE CL A 1002
source : AC5

22) chain A
residue 184
type
sequence S
description BINDING SITE FOR RESIDUE CL A 1003
source : AC6

23) chain A
residue 199
type
sequence D
description BINDING SITE FOR RESIDUE CL A 1003
source : AC6

24) chain A
residue 200
type
sequence T
description BINDING SITE FOR RESIDUE CL A 1003
source : AC6

25) chain A
residue 201
type
sequence A
description BINDING SITE FOR RESIDUE CL A 1003
source : AC6

26) chain A
residue 180
type
sequence N
description BINDING SITE FOR RESIDUE CL A 1005
source : AC7

27) chain A
residue 226
type
sequence G
description BINDING SITE FOR RESIDUE CL A 1005
source : AC7

28) chain A
residue 52
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 3000
source : AC8

29) chain A
residue 136
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 3000
source : AC8

30) chain A
residue 221
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 3000
source : AC8

31) chain A
residue 263
type
sequence F
description BINDING SITE FOR RESIDUE SO4 A 3000
source : AC8

32) chain A
residue 181
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 3002
source : AC9

33) chain A
residue 227
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 3002
source : AC9

34) chain A
residue 102-116
type prosite
sequence LVSASDDKTLKIWDV
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

35) chain A
residue 144-158
type prosite
sequence IVSGSFDESVRIWDV
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

36) chain A
residue 186-200
type prosite
sequence IVSSSYDGLCRIWDT
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

37) chain A
residue 274-288
type prosite
sequence IVSGSEDNLVYIWNL
description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV
source prosite : PS00678

38) chain A
residue 107
type SITE
sequence D
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

39) chain A
residue 133
type SITE
sequence F
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

40) chain A
residue 263
type SITE
sequence F
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

41) chain A
residue 322
type SITE
sequence E
description Important for interaction with histone H3
source Swiss-Prot : SWS_FT_FI1

42) chain A
residue 112
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI2

43) chain A
residue 46
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI3


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