eF-site ID 3upx-A PDB Code 3upx Chain A click to enlarge Title Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Calmodulin-domain protein kinase 1 Source Toxoplasma gondii (Q9BJF5_TOXGO) Sequence A:  TAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVIS KRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGY FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGIT YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFE ASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVILYIL LSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD LIRKMLTYVPSMRISARDALDHEWIQTYTKVPSLDNAILN IRQFQGTQKLAQAALLYMGSKLTSQDETKELTAIFHKMDK NGDGQLDRAELIEGYKELMRDASMLDASAVEHEVDQVLDI EYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTE LATIFGVSDVDSETWKSVLSEVDKNNDGEVDFDEFQQMLL KLCGN Description Functional site 1) chain A residue 57 type sequence L description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 2) chain A residue 65 type sequence V description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 3) chain A residue 78 type sequence A description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 4) chain A residue 80 type sequence K description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 5) chain A residue 112 type sequence M description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 6) chain A residue 126 type sequence L description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 7) chain A residue 129 type sequence E description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 8) chain A residue 131 type sequence Y description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 9) chain A residue 135 type sequence E description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 10) chain A residue 181 type sequence L description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 11) chain A residue 194 type sequence I description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 12) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE B6A A 1 source : AC1 13) chain A residue 57-80 type prosite sequence LGKGSFGEVILCKDKITGQECAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGSFGEVIlCkdkitgqe..........CAVK source prosite : PS00107 14) chain A residue 368-380 type prosite sequence DKNGDGQLDRAEL description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 15) chain A residue 451-463 type prosite sequence DSDNSGKISSTEL description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 16) chain A residue 485-497 type prosite sequence DKNNDGEVDFDEF description EF_HAND_1 EF-hand calcium-binding domain. DKNGDGQLDraEL source prosite : PS00018 17) chain A residue 170-182 type prosite sequence IVHRDLKPENLLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNLLL source prosite : PS00108

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