eF-site ID 3upn-A PDB Code 3upn Chain A click to enlarge Title Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex Classification Penicillin-binding protein/Antibiotic Compound Penicillin-binding protein A Source Mycobacterium tuberculosis (PBPA_MYCTU) Sequence A:  LLDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEV YAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRLADF FTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVV ALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGD NPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQL TAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCN TAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTV GPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITM RPYLVGSLKGPDLANISTTVRYQQRRAVSPQVAAKLTELM VGAEKVAQQKGAIPGVQIASKTGTAEHGTTPPHAWYIAFA PAQAPKVAVAVLVENGADRALAAPIGRAVIEAALQ Description Functional site 1) chain A residue 221 type sequence G description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 2) chain A residue 222 type sequence S description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 3) chain A residue 281 type sequence S description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 4) chain A residue 283 type sequence N description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 5) chain A residue 411 type sequence Q description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 6) chain A residue 425 type sequence T description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 7) chain A residue 426 type sequence G description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 8) chain A residue 427 type sequence T description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 9) chain A residue 473 type sequence A description BINDING SITE FOR RESIDUE IM2 A 800 source : AC1 10) chain A residue 222 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000250|UniProtKB:P0AD65 source Swiss-Prot : SWS_FT_FI1

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