eF-site ID 3uol-B PDB Code 3uol Chain B click to enlarge Title Aurora A in complex with SO2-162 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Aurora kinase A Source Homo sapiens (Human) (AURKA_HUMAN) Sequence B:  QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK AQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRV YLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSY CHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR DTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK PPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH NPSQRPMLREVLEHPWITANSSK Description Functional site 1) chain B residue 335 type sequence Q description BINDING SITE FOR RESIDUE EDO A 4 source : AC3 2) chain B residue 137 type sequence R description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 3) chain B residue 139 type sequence L description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 4) chain B residue 194 type sequence L description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 5) chain B residue 211 type sequence E description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 6) chain B residue 213 type sequence A description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 7) chain B residue 216 type sequence G description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 8) chain B residue 217 type sequence T description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 9) chain B residue 260 type sequence E description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 10) chain B residue 263 type sequence L description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 11) chain B residue 273 type sequence A description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 12) chain B residue 279 type sequence V description BINDING SITE FOR RESIDUE 0C7 B 1 source : AC7 13) chain B residue 199 type sequence Y description BINDING SITE FOR RESIDUE EDO B 2 source : AC8 14) chain B residue 200 type sequence F description BINDING SITE FOR RESIDUE EDO B 2 source : AC8 15) chain B residue 201 type sequence H description BINDING SITE FOR RESIDUE EDO B 2 source : AC8 16) chain B residue 366 type sequence H description BINDING SITE FOR RESIDUE EDO B 3 source : AC9 17) chain B residue 367 type sequence N description BINDING SITE FOR RESIDUE EDO B 3 source : AC9 18) chain B residue 130 type sequence L description BINDING SITE FOR RESIDUE EDO B 5 source : BC1 19) chain B residue 148 type sequence Y description BINDING SITE FOR RESIDUE EDO B 5 source : BC1 20) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE EDO B 5 source : BC1 21) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE EDO B 8 source : BC2 22) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE EDO B 9 source : BC3 23) chain B residue 351 type sequence F description BINDING SITE FOR RESIDUE EDO B 9 source : BC3 24) chain B residue 248 type sequence H description BINDING SITE FOR RESIDUE EDO B 11 source : BC4 25) chain B residue 308 type sequence E description BINDING SITE FOR RESIDUE EDO B 11 source : BC4 26) chain B residue 373 type sequence M description BINDING SITE FOR RESIDUE EDO B 11 source : BC4 27) chain B residue 374 type sequence L description BINDING SITE FOR RESIDUE EDO B 11 source : BC4 28) chain B residue 256 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027, ECO:0000269|PubMed:14580337 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 274 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 30) chain B residue 143 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 31) chain B residue 162 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 32) chain B residue 211 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 33) chain B residue 260 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27837025, ECO:0007744|PDB:5G1X source Swiss-Prot : SWS_FT_FI2 34) chain B residue 287 type MOD_RES sequence D description Phosphothreonine => ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:19668197 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 288 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:16246726, ECO:0000269|PubMed:18662907, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:26246606 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 342 type MOD_RES sequence S description Phosphoserine; by PKA and PAK => ECO:0000269|PubMed:16246726 source Swiss-Prot : SWS_FT_FI5 37) chain B residue 258 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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