eF-site ID 3uo8-BCLM PDB Code 3uo8 Chain B, C, L, M click to enlarge Title Crystal structure of the MALT1 paracaspase (P1 form) Classification HYDROLASE/HYDROLASE INHIBITOR Compound Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Source Homo sapiens (Human) (3UO8) Sequence B:  MLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLD FKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGY ENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLN VFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAE AFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMG KCHLTKGKQALEIRSSLSEKRALTDPIQWAKAHELPESMC LKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAY VTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTR LSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPL IAKL C:  MLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLD FKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGY ENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLN VFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAE AFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMG KCHLTKGKQALEIRSSLSEKRALTDPIQNLQWAKAHELPE SMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMC DAYVTDFPLDLDIDPKDANKGTPEETGSYLVSHCLYTRLS SLQKLKEHLVFTVCLSYQYSGLTVEDKQEVNVGKPLIAKL DMH L:  VRPR M:  VRPR Description Functional site 1) chain B residue 359 type sequence L description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 2) chain B residue 361 type sequence A description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 3) chain B residue 362 type sequence P description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 4) chain B residue 365 type sequence D description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 5) chain B residue 414 type sequence G description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 6) chain B residue 415 type sequence H description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 7) chain B residue 416 type sequence G description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 8) chain B residue 462 type sequence D description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 9) chain B residue 464 type sequence C description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 10) chain B residue 497 type sequence E description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 11) chain B residue 498 type sequence A description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 12) chain B residue 499 type sequence F description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 13) chain B residue 500 type sequence E description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 14) chain B residue 502 type sequence Q description BINDING SITE FOR CHAIN L OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC1 15) chain C residue 360 type sequence K description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 16) chain C residue 361 type sequence A description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 17) chain C residue 362 type sequence P description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 18) chain C residue 365 type sequence D description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 19) chain C residue 413 type sequence A description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 20) chain C residue 414 type sequence G description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 21) chain C residue 415 type sequence H description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 22) chain C residue 416 type sequence G description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 23) chain C residue 462 type sequence D description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 24) chain C residue 464 type sequence C description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 25) chain C residue 497 type sequence E description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 26) chain C residue 498 type sequence A description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 27) chain C residue 499 type sequence F description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 28) chain C residue 500 type sequence E description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 29) chain C residue 501 type sequence I description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 30) chain C residue 502 type sequence Q description BINDING SITE FOR CHAIN M OF Z-VAL-ARG-PRO-DL-ARG-FLUOROMETHYLKETONE source : AC2 31) chain B residue 415 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 464 type ACT_SITE sequence C description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain C residue 415 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 34) chain C residue 464 type ACT_SITE sequence C description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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