eF-site ID 3umo-AB PDB Code 3umo Chain A, B click to enlarge Title Crystal structure of the Phosphofructokinase-2 from Escherichia coli in complex with Potassium Classification TRANSFERASE Compound 6-phosphofructokinase isozyme 2 Source Escherichia coli (strain K12) (K6PF2_ECOLI) Sequence A:  MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGG GINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPV ATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQ LEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQG IRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELT QPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQ VVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGV AAGSAATLNQGTRLCSHDDTQKIYAYLSR B:  MVRIYTLTLAPSLDSATITPQIYPEGKLRCTAPVFEPGGG GINVARAIAHLGGSATAIFPAGGATGEHLVSLLADENVPV ATVEAKDWTRQNLHVHVEASGEQYRFVMPGAALNEDEFRQ LEEQVLEIESGAILVISGSLPPGVKLEKLTQLISAAQKQG IRCIVDSSGEALSAALAIGNIELVKPNQKELSALVNRELT QPDDVRKAAQEIVNSGKAKRVVVSLGPQGALGVDSENCIQ VVPPPVKSQSTVGAGDSMVGAMTLKLAENASLEEMVRFGV AAGSAATLNQGTRLCSHDDTQKIYAYLSR Description Functional site 1) chain A residue 185 type sequence K description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 2) chain A residue 187 type sequence N description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 3) chain A residue 224 type sequence S description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 4) chain A residue 225 type sequence L description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 5) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 6) chain A residue 227 type sequence P description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 7) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 8) chain A residue 251 type sequence T description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 9) chain A residue 254 type sequence A description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 10) chain A residue 255 type sequence G description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 11) chain A residue 258 type sequence M description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 12) chain A residue 280 type sequence V description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 13) chain A residue 283 type sequence G description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 14) chain A residue 284 type sequence S description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 15) chain A residue 287 type sequence T description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 16) chain B residue 27 type sequence K description BINDING SITE FOR RESIDUE ATP A 313 source : AC3 17) chain A residue 250 type sequence S description BINDING SITE FOR RESIDUE K A 314 source : AC4 18) chain A residue 252 type sequence V description BINDING SITE FOR RESIDUE K A 314 source : AC4 19) chain A residue 286 type sequence A description BINDING SITE FOR RESIDUE K A 314 source : AC4 20) chain A residue 289 type sequence N description BINDING SITE FOR RESIDUE K A 314 source : AC4 21) chain A residue 291 type sequence G description BINDING SITE FOR RESIDUE K A 314 source : AC4 22) chain A residue 293 type sequence R description BINDING SITE FOR RESIDUE K A 314 source : AC4 23) chain A residue 23 type sequence Y description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 24) chain A residue 24 type sequence P description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 25) chain A residue 26 type sequence G description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 26) chain A residue 27 type sequence K description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 27) chain A residue 102 type sequence E description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 28) chain B residue 187 type sequence N description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 29) chain B residue 189 type sequence K description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 30) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 31) chain B residue 227 type sequence P description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 32) chain B residue 251 type sequence T description BINDING SITE FOR RESIDUE ATP A 315 source : AC6 33) chain A residue 187 type sequence N description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 34) chain A residue 189 type sequence K description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 35) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 36) chain A residue 251 type sequence T description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 37) chain B residue 23 type sequence Y description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 38) chain B residue 26 type sequence G description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 39) chain B residue 27 type sequence K description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 40) chain B residue 102 type sequence E description BINDING SITE FOR RESIDUE ATP B 312 source : AC7 41) chain A residue 27 type sequence K description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 42) chain B residue 185 type sequence K description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 43) chain B residue 187 type sequence N description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 44) chain B residue 224 type sequence S description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 45) chain B residue 225 type sequence L description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 46) chain B residue 226 type sequence G description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 47) chain B residue 227 type sequence P description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 48) chain B residue 229 type sequence G description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 49) chain B residue 254 type sequence A description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 50) chain B residue 255 type sequence G description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 51) chain B residue 258 type sequence M description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 52) chain B residue 280 type sequence V description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 53) chain B residue 283 type sequence G description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 54) chain B residue 284 type sequence S description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 55) chain B residue 287 type sequence T description BINDING SITE FOR RESIDUE ATP B 313 source : AC9 56) chain B residue 250 type sequence S description BINDING SITE FOR RESIDUE K B 314 source : BC1 57) chain B residue 252 type sequence V description BINDING SITE FOR RESIDUE K B 314 source : BC1 58) chain B residue 286 type sequence A description BINDING SITE FOR RESIDUE K B 314 source : BC1 59) chain B residue 289 type sequence N description BINDING SITE FOR RESIDUE K B 314 source : BC1 60) chain B residue 291 type sequence G description BINDING SITE FOR RESIDUE K B 314 source : BC1 61) chain B residue 293 type sequence R description BINDING SITE FOR RESIDUE K B 314 source : BC1 62) chain A residue 256 type ACT_SITE sequence D description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 256 type ACT_SITE sequence D description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 256 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 65) chain A residue 90 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 66) chain A residue 139 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 67) chain A residue 256 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 68) chain B residue 12 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 69) chain B residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 70) chain B residue 90 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 71) chain B residue 139 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 72) chain A residue 12 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI2 73) chain A residue 39 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 74) chain A residue 27 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18762190, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI3 75) chain B residue 27 type BINDING sequence K description BINDING => ECO:0000269|PubMed:18762190, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI3 76) chain A residue 185 type BINDING sequence K description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 77) chain A residue 224 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 78) chain A residue 248 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 79) chain A residue 280 type BINDING sequence V description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 80) chain A residue 284 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 81) chain B residue 185 type BINDING sequence K description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 82) chain B residue 224 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 83) chain B residue 248 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 84) chain B residue 280 type BINDING sequence V description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 85) chain B residue 284 type BINDING sequence S description in other chain => ECO:0000269|PubMed:18762190, ECO:0000269|PubMed:23823238, ECO:0000269|Ref.10, ECO:0000269|Ref.11, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI4 86) chain A residue 187 type BINDING sequence N description in other chain => ECO:0000269|PubMed:18762190, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI5 87) chain B residue 187 type BINDING sequence N description in other chain => ECO:0000269|PubMed:18762190, ECO:0007744|PDB:3CQD source Swiss-Prot : SWS_FT_FI5 88) chain B residue 289 type BINDING sequence N description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 89) chain B residue 291 type BINDING sequence G description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 90) chain B residue 293 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 91) chain A residue 291 type BINDING sequence G description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 92) chain A residue 293 type BINDING sequence R description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 93) chain B residue 250 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 94) chain B residue 252 type BINDING sequence V description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 95) chain B residue 286 type BINDING sequence A description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 96) chain A residue 250 type BINDING sequence S description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 97) chain A residue 252 type BINDING sequence V description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 98) chain A residue 286 type BINDING sequence A description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 99) chain A residue 289 type BINDING sequence N description BINDING => ECO:0000269|PubMed:23823238 source Swiss-Prot : SWS_FT_FI7 100) chain A residue 38-62 type prosite sequence GGGGINVARAIAHLGGSATAIFPAG description PFKB_KINASES_1 pfkB family of carbohydrate kinases signature 1. GGgGiNVAraIaHLGgsataifpaG source prosite : PS00583 101) chain A residue 250-263 type prosite sequence STVGAGDSMVGAMT description PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. STvGAGDsmvGAMT source prosite : PS00584 102) chain A residue 190 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI6 103) chain B residue 190 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI6

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