eF-site ID 3umi-A PDB Code 3umi Chain A click to enlarge Title X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with zinc Classification METAL BINDING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence A:  ENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLP KADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKD RQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQS LSLLYNVPAVAEEIQDEVDELLQ Description Functional site 1) chain A residue 362 type sequence E description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 2) chain A residue 365 type sequence E description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 3) chain A residue 382 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 4) chain A residue 432 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 5) chain A residue 436 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC2 6) chain A residue 387 type sequence E description BINDING SITE FOR RESIDUE CD A 2 source : AC3 7) chain A residue 391 type sequence N description BINDING SITE FOR RESIDUE CD A 2 source : AC3 8) chain A residue 429 type sequence D description BINDING SITE FOR RESIDUE CD A 2 source : AC3 9) chain A residue 458 type sequence H description BINDING SITE FOR RESIDUE CD A 2 source : AC3 10) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE CD A 3 source : AC4 11) chain A residue 399 type sequence E description BINDING SITE FOR RESIDUE CD A 4 source : AC5 12) chain A residue 439 type sequence H description BINDING SITE FOR RESIDUE CD A 4 source : AC5 13) chain A residue 327 type sequence H description BINDING SITE FOR RESIDUE CD A 5 source : AC6 14) chain A residue 368 type sequence E description BINDING SITE FOR RESIDUE CD A 5 source : AC6 15) chain A residue 392 type sequence D description BINDING SITE FOR RESIDUE CD A 5 source : AC6 16) chain A residue 362 type sequence E description BINDING SITE FOR RESIDUE CD A 6 source : AC7 17) chain A residue 365 type sequence E description BINDING SITE FOR RESIDUE CD A 6 source : AC7 18) chain A residue 329 type sequence E description BINDING SITE FOR RESIDUE CD A 7 source : AC8 19) chain A residue 484 type sequence Q description BINDING SITE FOR RESIDUE CD A 7 source : AC8 20) chain A residue 488 type sequence D description BINDING SITE FOR RESIDUE CD A 7 source : AC8 21) chain A residue 359 type sequence H description BINDING SITE FOR RESIDUE CD A 8 source : AC9 22) chain A residue 321 type sequence E description BINDING SITE FOR RESIDUE CD A 9 source : BC1 23) chain A residue 400 type sequence N description BINDING SITE FOR RESIDUE CD A 9 source : BC1 24) chain A residue 366 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 422 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 467 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI3

Display surface Download Links