eF-site ID 3umh-A PDB Code 3umh Chain A click to enlarge Title X-ray structure of the E2 domain of the human amyloid precursor protein (APP) in complex with cadmium Classification METAL BINDING PROTEIN Compound Amyloid beta A4 protein Source Homo sapiens (Human) (A4_HUMAN) Sequence A:  HAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLND RRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQH TLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSL LYNVPAVAEEIQDEVDELLQ Description Functional site 1) chain A residue 399 type sequence E description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 2) chain A residue 439 type sequence H description BINDING SITE FOR RESIDUE ACT A 601 source : AC1 3) chain A residue 362 type sequence E description BINDING SITE FOR RESIDUE ACT A 602 source : AC2 4) chain A residue 365 type sequence E description BINDING SITE FOR RESIDUE ACT A 602 source : AC2 5) chain A residue 313 type sequence H description BINDING SITE FOR RESIDUE CD A 1 source : AC3 6) chain A residue 382 type sequence H description BINDING SITE FOR RESIDUE CD A 1 source : AC3 7) chain A residue 432 type sequence H description BINDING SITE FOR RESIDUE CD A 1 source : AC3 8) chain A residue 436 type sequence H description BINDING SITE FOR RESIDUE CD A 1 source : AC3 9) chain A residue 387 type sequence E description BINDING SITE FOR RESIDUE CD A 2 source : AC4 10) chain A residue 391 type sequence N description BINDING SITE FOR RESIDUE CD A 2 source : AC4 11) chain A residue 429 type sequence D description BINDING SITE FOR RESIDUE CD A 2 source : AC4 12) chain A residue 433 type sequence T description BINDING SITE FOR RESIDUE CD A 2 source : AC4 13) chain A residue 458 type sequence H description BINDING SITE FOR RESIDUE CD A 2 source : AC4 14) chain A residue 444 type sequence D description BINDING SITE FOR RESIDUE CD A 3 source : AC5 15) chain A residue 399 type sequence E description BINDING SITE FOR RESIDUE CD A 4 source : AC6 16) chain A residue 439 type sequence H description BINDING SITE FOR RESIDUE CD A 4 source : AC6 17) chain A residue 327 type sequence H description BINDING SITE FOR RESIDUE CD A 5 source : AC7 18) chain A residue 368 type sequence E description BINDING SITE FOR RESIDUE CD A 5 source : AC7 19) chain A residue 392 type sequence D description BINDING SITE FOR RESIDUE CD A 5 source : AC7 20) chain A residue 362 type sequence E description BINDING SITE FOR RESIDUE CD A 6 source : AC8 21) chain A residue 365 type sequence E description BINDING SITE FOR RESIDUE CD A 6 source : AC8 22) chain A residue 359 type sequence H description BINDING SITE FOR RESIDUE CD A 7 source : AC9 23) chain A residue 329 type sequence E description BINDING SITE FOR RESIDUE CD A 8 source : BC1 24) chain A residue 488 type sequence D description BINDING SITE FOR RESIDUE CD A 8 source : BC1 25) chain A residue 321 type sequence E description BINDING SITE FOR RESIDUE CD A 9 source : BC2 26) chain A residue 366 type MOD_RES sequence S description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 422 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:26091039 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 467 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI3

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