eF-site ID 3uiv-H
PDB Code 3uiv
Chain H

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Title Human serum albumin-myristate-amantadine hydrochloride complex
Classification LIPID BINDING PROTEIN
Compound Serum albumin
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence H:  HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKL
VNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRE
TYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDV
MCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYK
AAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCAS
LQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVH
TECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKP
LLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEA
KDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCA
AADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYK
FQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPE
AKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLV
NRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQ
IKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKAD
DKETCFAEEGKKLVAASQAALG
Description


Functional site
1) chain H
residue 117
type
sequence R
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
2) chain H
residue 123
type
sequence M
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
3) chain H
residue 138
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
4) chain H
residue 158
type
sequence A
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
5) chain H
residue 161
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
6) chain H
residue 165
type
sequence F
description BINDING SITE FOR RESIDUE MYR H 1001
source : AC7
7) chain H
residue 150
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1002
source : AC8
8) chain H
residue 254
type
sequence A
description BINDING SITE FOR RESIDUE MYR H 1002
source : AC8
9) chain H
residue 257
type
sequence R
description BINDING SITE FOR RESIDUE MYR H 1002
source : AC8
10) chain H
residue 258
type
sequence A
description BINDING SITE FOR RESIDUE MYR H 1002
source : AC8
11) chain H
residue 287
type
sequence S
description BINDING SITE FOR RESIDUE MYR H 1002
source : AC8
12) chain H
residue 342
type
sequence S
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
13) chain H
residue 344
type
sequence V
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
14) chain H
residue 348
type
sequence R
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
15) chain H
residue 388
type
sequence I
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
16) chain H
residue 391
type
sequence N
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
17) chain H
residue 446
type
sequence M
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
18) chain H
residue 485
type
sequence R
description BINDING SITE FOR RESIDUE MYR H 1003
source : AC9
19) chain H
residue 387
type
sequence L
description BINDING SITE FOR RESIDUE MYR H 1004
source : BC1
20) chain H
residue 411
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1004
source : BC1
21) chain H
residue 415
type
sequence V
description BINDING SITE FOR RESIDUE MYR H 1004
source : BC1
22) chain H
residue 489
type
sequence S
description BINDING SITE FOR RESIDUE MYR H 1004
source : BC1
23) chain H
residue 401
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
24) chain H
residue 405
type
sequence N
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
25) chain H
residue 507
type
sequence F
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
26) chain H
residue 525
type
sequence K
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
27) chain H
residue 528
type
sequence A
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
28) chain H
residue 579
type
sequence S
description BINDING SITE FOR RESIDUE MYR H 1005
source : BC2
29) chain H
residue 199
type
sequence K
description BINDING SITE FOR RESIDUE MYR H 1006
source : BC3
30) chain H
residue 211
type
sequence F
description BINDING SITE FOR RESIDUE MYR H 1006
source : BC3
31) chain H
residue 214
type
sequence W
description BINDING SITE FOR RESIDUE MYR H 1006
source : BC3
32) chain H
residue 238
type
sequence L
description BINDING SITE FOR RESIDUE MYR H 1006
source : BC3
33) chain H
residue 242
type
sequence H
description BINDING SITE FOR RESIDUE MYR H 1006
source : BC3
34) chain H
residue 150
type
sequence Y
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
35) chain H
residue 153
type
sequence E
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
36) chain H
residue 192
type
sequence S
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
37) chain H
residue 196
type
sequence Q
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
38) chain H
residue 242
type
sequence H
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
39) chain H
residue 245
type
sequence C
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
40) chain H
residue 257
type
sequence R
description BINDING SITE FOR RESIDUE MYR H 1007
source : BC4
41) chain H
residue 238
type
sequence L
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
42) chain H
residue 260
type
sequence L
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
43) chain H
residue 264
type
sequence I
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
44) chain H
residue 287
type
sequence S
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
45) chain H
residue 290
type
sequence I
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
46) chain H
residue 291
type
sequence A
description BINDING SITE FOR RESIDUE 308 H 1008
source : BC5
47) chain H
residue 3
type BINDING
sequence H
description BINDING => ECO:0000250|UniProtKB:P02770
source Swiss-Prot : SWS_FT_FI1
48) chain H
residue 252
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
49) chain H
residue 255
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
50) chain H
residue 259
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
51) chain H
residue 6
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
52) chain H
residue 13
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
53) chain H
residue 244
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P02769
source Swiss-Prot : SWS_FT_FI2
54) chain H
residue 67
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28567254, ECO:0007744|PDB:5IJF
source Swiss-Prot : SWS_FT_FI3
55) chain H
residue 247
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:28567254, ECO:0007744|PDB:5IJF
source Swiss-Prot : SWS_FT_FI3
56) chain H
residue 249
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:28567254, ECO:0007744|PDB:5IJF
source Swiss-Prot : SWS_FT_FI3
57) chain H
residue 240
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:656055
source Swiss-Prot : SWS_FT_FI4
58) chain H
residue 83
type MOD_RES
sequence T
description Phosphothreonine; by FAM20C => ECO:0000269|PubMed:26091039
source Swiss-Prot : SWS_FT_FI10
59) chain H
residue 4
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
60) chain H
residue 20
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
61) chain H
residue 41
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
62) chain H
residue 64
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
63) chain H
residue 73
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
64) chain H
residue 93
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
65) chain H
residue 106
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
66) chain H
residue 136
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
67) chain H
residue 159
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
68) chain H
residue 174
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
69) chain H
residue 181
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
70) chain H
residue 190
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
71) chain H
residue 195
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
72) chain H
residue 205
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
73) chain H
residue 212
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
74) chain H
residue 240
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
75) chain H
residue 262
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
76) chain H
residue 274
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
77) chain H
residue 286
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
78) chain H
residue 359
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
79) chain H
residue 372
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
80) chain H
residue 389
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
81) chain H
residue 402
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
82) chain H
residue 414
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
83) chain H
residue 432
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
84) chain H
residue 436
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
85) chain H
residue 466
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
86) chain H
residue 475
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
87) chain H
residue 500
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
88) chain H
residue 519
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
89) chain H
residue 524
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
90) chain H
residue 538
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
91) chain H
residue 541
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
92) chain H
residue 557
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
93) chain H
residue 560
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
94) chain H
residue 564
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
95) chain H
residue 574
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI5
96) chain H
residue 199
type SITE
sequence K
description Aspirin-acetylated lysine
source Swiss-Prot : SWS_FT_FI6
97) chain H
residue 5
type MOD_RES
sequence S
description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
source Swiss-Prot : SWS_FT_FI7
98) chain H
residue 65
type MOD_RES
sequence S
description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI9
99) chain H
residue 273
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI12
100) chain H
residue 205
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI11
101) chain H
residue 436
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI11
102) chain H
residue 519
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI11
103) chain H
residue 564
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI11
104) chain H
residue 419
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI13
105) chain H
residue 534
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
source Swiss-Prot : SWS_FT_FI16
106) chain H
residue 12
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI17
107) chain H
residue 281
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI17
108) chain H
residue 317
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI17
109) chain H
residue 439
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI17
110) chain H
residue 199
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:3759977, ECO:0000269|PubMed:6853480
source Swiss-Prot : SWS_FT_FI19
111) chain H
residue 233
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI20
112) chain H
residue 351
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI20
113) chain H
residue 318
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine; in variant Redhill
source Swiss-Prot : SWS_FT_FI21
114) chain H
residue 494
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine; in variant Casebrook
source Swiss-Prot : SWS_FT_FI22
115) chain H
residue 420
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI14
116) chain H
residue 422
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI14
117) chain H
residue 489
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI15
118) chain H
residue 51
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
119) chain H
residue 137
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
120) chain H
residue 162
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
121) chain H
residue 225
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
122) chain H
residue 276
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
123) chain H
residue 313
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
124) chain H
residue 323
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
125) chain H
residue 378
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
126) chain H
residue 413
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
127) chain H
residue 444
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
128) chain H
residue 536
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
129) chain H
residue 545
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
130) chain H
residue 573
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI18
131) chain H
residue 525
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977, ECO:0000269|PubMed:6706980, ECO:0000269|PubMed:6853480
source Swiss-Prot : SWS_FT_FI23
132) chain H
residue 534
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI24
133) chain H
residue 58
type MOD_RES
sequence S
description Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8

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