eF-site ID 3ugb-AB PDB Code 3ugb Chain A, B click to enlarge Title UbcH5c~Ubiquitin Conjugate Classification LIGASE/PROTEIN BINDING Compound Ubiquitin-conjugating enzyme E2 D3 Source Homo sapiens (Human) (UBC_HUMAN) Sequence A:  ALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPN DSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSN GSISLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVP EIARIYKTDRDKYNRISREWTQKYAM B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 55 type sequence H description BINDING SITE FOR RESIDUE GOL A 201 source : AC1 2) chain A residue 57 type sequence P description BINDING SITE FOR RESIDUE GOL A 201 source : AC1 3) chain A residue 58 type sequence T description BINDING SITE FOR RESIDUE GOL A 201 source : AC1 4) chain A residue 66 type sequence K description BINDING SITE FOR RESIDUE GOL A 201 source : AC1 5) chain A residue 44 type sequence P description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 6) chain A residue 110 type sequence L description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 7) chain A residue 111 type sequence C description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 8) chain A residue 113 type sequence P description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 9) chain A residue 127 type sequence Y description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 10) chain A residue 131 type sequence R description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 11) chain A residue 134 type sequence Y description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 12) chain A residue 135 type sequence N description BINDING SITE FOR RESIDUE GOL A 202 source : AC2 13) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 14) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 16) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 17) chain B residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000269|PubMed:28525742 source Swiss-Prot : SWS_FT_FI5 18) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 19) chain B residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI7 20) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 21) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 22) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 23) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 24) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 25) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 26) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 27) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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