eF-site ID 3ua9-A PDB Code 3ua9 Chain A click to enlarge Title Crystal structure of human tankyrase 2 in complex with a selective inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tankyrase-2 Source Homo sapiens (Human) (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLIT YQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 5) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1163 source : AC2 6) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1163 source : AC2 7) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1163 source : AC2 8) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1163 source : AC2 9) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1163 source : AC2 10) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 11) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 12) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 13) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 3 source : AC3 14) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 15) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 16) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 17) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 18) chain A residue 1038 type sequence A description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 19) chain A residue 1043 type sequence G description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 20) chain A residue 1044 type sequence F description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 21) chain A residue 1045 type sequence D description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 22) chain A residue 1048 type sequence H description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 23) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 24) chain A residue 1058 type sequence G description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 25) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 26) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE IWR A 2 source : AC4 27) chain A residue 1006 type sequence W description BINDING SITE FOR RESIDUE PEG A 1164 source : AC5 28) chain A residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG A 1164 source : AC5 29) chain A residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG A 1164 source : AC5 30) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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