eF-site ID 3u9h-AB PDB Code 3u9h Chain A, B click to enlarge Title Complex structure of human tankyrase 2 with nicotinamide Classification TRANSFERASE Compound Tankyrase-2 Source null (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYL ITYQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 1 source : AC1 5) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3 source : AC2 6) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 3 source : AC2 7) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3 source : AC2 8) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 3 source : AC2 9) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 3 source : AC2 10) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 4 source : AC3 11) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 4 source : AC3 12) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 4 source : AC3 13) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 4 source : AC3 14) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 15) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 16) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 17) chain A residue 1061 type sequence F description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 18) chain A residue 1062 type sequence A description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 19) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 20) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 21) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE NCA A 1163 source : AC4 22) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 23) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 24) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 25) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 26) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 27) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 1164 source : AC5 28) chain A residue 1001 type sequence C description BINDING SITE FOR RESIDUE PEG A 2 source : AC6 29) chain A residue 1002 type sequence N description BINDING SITE FOR RESIDUE PEG A 2 source : AC6 30) chain A residue 1006 type sequence W description BINDING SITE FOR RESIDUE PEG A 2 source : AC6 31) chain A residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG A 2 source : AC6 32) chain A residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG A 2 source : AC6 33) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2 source : AC7 34) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2 source : AC7 35) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2 source : AC7 36) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2 source : AC7 37) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1 source : AC8 38) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1 source : AC8 39) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1 source : AC8 40) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1163 source : AC9 41) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1163 source : AC9 42) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1163 source : AC9 43) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1163 source : AC9 44) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1163 source : AC9 45) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 46) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 47) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 48) chain B residue 1061 type sequence F description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 49) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 50) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 51) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE NCA B 1164 source : BC1 52) chain B residue 999 type sequence K description BINDING SITE FOR RESIDUE PEG B 1165 source : BC2 53) chain B residue 1006 type sequence W description BINDING SITE FOR RESIDUE PEG B 1165 source : BC2 54) chain B residue 1022 type sequence N description BINDING SITE FOR RESIDUE PEG B 1165 source : BC2 55) chain B residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG B 1165 source : BC2 56) chain B residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG B 1165 source : BC2 57) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 61) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 62) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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