eF-site ID 3u4s-B PDB Code 3u4s Chain B click to enlarge Title Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine Classification OXIDOREDUCTASE/OXIDOREDUCTASE SUBSTRATE Compound Lysine-specific demethylase 4A Source Homo sapiens (Human) (H31_HUMAN) Sequence B:  ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLA KVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQY NIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNL TFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESG ITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEP KSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLI SPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNC AESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQ PERYKLWKAGKDNTVIDHTLPTPEAAEFL Description Functional site 1) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE NI B 501 source : AC4 2) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE NI B 501 source : AC4 3) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE NI B 501 source : AC4 4) chain B residue 234 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC5 5) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE ZN B 502 source : AC5 6) chain B residue 306 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC5 7) chain B residue 308 type sequence C description BINDING SITE FOR RESIDUE ZN B 502 source : AC5 8) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 9) chain B residue 177 type sequence Y description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 10) chain B residue 185 type sequence F description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 11) chain B residue 188 type sequence H description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 12) chain B residue 190 type sequence E description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 13) chain B residue 196 type sequence S description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 14) chain B residue 198 type sequence N description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 15) chain B residue 206 type sequence K description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 16) chain B residue 276 type sequence H description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 17) chain B residue 288 type sequence S description BINDING SITE FOR RESIDUE 08P B 503 source : AC6 18) chain B residue 170 type catalytic sequence G description 370 source MCSA : MCSA2 19) chain B residue 177 type catalytic sequence Y description 370 source MCSA : MCSA2 20) chain B residue 188 type catalytic sequence H description 370 source MCSA : MCSA2 21) chain B residue 190 type catalytic sequence E description 370 source MCSA : MCSA2 22) chain B residue 276 type catalytic sequence H description 370 source MCSA : MCSA2 23) chain B residue 288 type catalytic sequence S description 370 source MCSA : MCSA2 24) chain B residue 132 type MOD_RES sequence Y description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 198 type MOD_RES sequence N description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 206 type MOD_RES sequence K description Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 188 type MOD_RES sequence H description N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 276 type MOD_RES sequence H description N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 234 type MOD_RES sequence C description Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 source Swiss-Prot : SWS_FT_FI4 30) chain B residue 240 type MOD_RES sequence H description Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 source Swiss-Prot : SWS_FT_FI4 31) chain B residue 306 type MOD_RES sequence C description Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 source Swiss-Prot : SWS_FT_FI4 32) chain B residue 308 type MOD_RES sequence C description Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 source Swiss-Prot : SWS_FT_FI4

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