eF-site ID 3u30-D
PDB Code 3u30
Chain D

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Title Crystal structure of a linear-specific Ubiquitin fab bound to linear ubiquitin
Classification IMMUNE SYSTEM
Compound linear di-ubiquitin
Source Homo sapiens (Human) (3U30)
Sequence D:  QIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQ
RLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFV
KTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIF
AGKQLEDGRTLSDYNIQKESTLHLV
Description


Functional site

1) chain D
residue 37
type SITE
sequence P
description Interacts with activating enzyme
source Swiss-Prot : SWS_FT_FI1

2) chain D
residue 55
type SITE
sequence T
description Interacts with activating enzyme
source Swiss-Prot : SWS_FT_FI1

3) chain D
residue 31
type CROSSLNK
sequence Q
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
source Swiss-Prot : SWS_FT_FI10

4) chain D
residue 46
type CROSSLNK
sequence A
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
source Swiss-Prot : SWS_FT_FI11

5) chain D
residue 51
type SITE
sequence E
description Essential for function
source Swiss-Prot : SWS_FT_FI2

6) chain D
residue 48
type MOD_RES
sequence K
description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
source Swiss-Prot : SWS_FT_FI3

7) chain D
residue 49
type MOD_RES
sequence Q
description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457
source Swiss-Prot : SWS_FT_FI4

8) chain D
residue 59
type MOD_RES
sequence Y
description ADP-ribosylglycine => ECO:0000269|PubMed:28525742
source Swiss-Prot : SWS_FT_FI5

9) chain D
residue 10
type CROSSLNK
sequence G
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
source Swiss-Prot : SWS_FT_FI6

10) chain D
residue 59
type CROSSLNK
sequence Y
description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
source Swiss-Prot : SWS_FT_FI7

11) chain D
residue 12
type CROSSLNK
sequence T
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
source Swiss-Prot : SWS_FT_FI8

12) chain D
residue 16
type CROSSLNK
sequence E
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
source Swiss-Prot : SWS_FT_FI9


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