eF-site ID 3u0z-A PDB Code 3u0z Chain A click to enlarge Title Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels Classification TRANSPORT PROTEIN Compound Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Source Mus musculus (Mouse) (HCN1_MOUSE) Sequence A:  DSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ GKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANAD PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVA GVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCR LYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNS Description Functional site 1) chain A residue 511 type sequence V description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 2) chain A residue 527 type sequence F description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 3) chain A residue 528 type sequence G description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 4) chain A residue 529 type sequence E description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 5) chain A residue 530 type sequence I description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 6) chain A residue 531 type sequence C description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 7) chain A residue 538 type sequence R description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 8) chain A residue 539 type sequence T description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 9) chain A residue 540 type sequence A description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 10) chain A residue 579 type sequence R description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 11) chain A residue 582 type sequence R description BINDING SITE FOR RESIDUE CMP A 646 source : AC1 12) chain A residue 528 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22006928, ECO:0007744|PDB:3U0Z source Swiss-Prot : SWS_FT_FI1 13) chain A residue 538 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22006928, ECO:0007744|PDB:3U0Z source Swiss-Prot : SWS_FT_FI1 14) chain A residue 579 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22006928, ECO:0007744|PDB:3U0Z source Swiss-Prot : SWS_FT_FI1 15) chain A residue 491-507 type prosite sequence IIREGAVGKKMYFIQHG description CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGAvGKkMYFIqhG source prosite : PS00888

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