eF-site ID 3tzs-ABC PDB Code 3tzs Chain A, B, C click to enlarge Title Crystal structure of Neutrophil gelatinase-associated lipocalin NGAL (C87S mutant) in complex with fragment 1026, phenylurea Classification APOPTOSIS Compound Neutrophil gelatinase-associated lipocalin Source (NGAL_HUMAN) Sequence A:  TSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILR EDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTF VPGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFF KKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPE NHIVFPVPIDQCID B:  SDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILRE DKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFV PGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFK KVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPEN HIVFPVPIDQCID C:  SDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILRE DKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFV PGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFK KVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPEN HIVFPVPIDQCID Description Functional site 1) chain A residue 41 type sequence I description BINDING SITE FOR RESIDUE PHU A 201 source : AC1 2) chain A residue 123 type sequence F description BINDING SITE FOR RESIDUE PHU A 201 source : AC1 3) chain A residue 125 type sequence K description BINDING SITE FOR RESIDUE PHU A 201 source : AC1 4) chain A residue 132 type sequence Y description BINDING SITE FOR RESIDUE PHU A 201 source : AC1 5) chain A residue 75 type sequence K description BINDING SITE FOR RESIDUE SO4 A 206 source : AC2 6) chain C residue 8 type sequence I description BINDING SITE FOR RESIDUE SO4 A 206 source : AC2 7) chain C residue 164 type sequence N description BINDING SITE FOR RESIDUE SO4 A 206 source : AC2 8) chain C residue 165 type sequence H description BINDING SITE FOR RESIDUE SO4 A 206 source : AC2 9) chain A residue 54 type sequence T description BINDING SITE FOR RESIDUE CL A 183 source : AC3 10) chain A residue 81 type sequence R description BINDING SITE FOR RESIDUE CL A 183 source : AC3 11) chain A residue 138 type sequence Y description BINDING SITE FOR RESIDUE CL A 183 source : AC3 12) chain A residue 79 type sequence W description BINDING SITE FOR RESIDUE SO4 A 184 source : AC4 13) chain A residue 81 type sequence R description BINDING SITE FOR RESIDUE SO4 A 184 source : AC4 14) chain A residue 106 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 184 source : AC4 15) chain A residue 125 type sequence K description BINDING SITE FOR RESIDUE SO4 A 184 source : AC4 16) chain A residue 134 type sequence K description BINDING SITE FOR RESIDUE SO4 A 184 source : AC4 17) chain A residue 23 type sequence Q description BINDING SITE FOR RESIDUE PHU A 185 source : AC5 18) chain A residue 26 type sequence Q description BINDING SITE FOR RESIDUE PHU A 185 source : AC5 19) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE PHU A 185 source : AC5 20) chain B residue 26 type sequence Q description BINDING SITE FOR RESIDUE PHU A 185 source : AC5 21) chain C residue 26 type sequence Q description BINDING SITE FOR RESIDUE PHU A 185 source : AC5 22) chain A residue 93 type sequence T description BINDING SITE FOR RESIDUE EDO A 186 source : AC6 23) chain A residue 94 type sequence L description BINDING SITE FOR RESIDUE EDO A 186 source : AC6 24) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE EDO A 186 source : AC6 25) chain A residue 106 type sequence Y description BINDING SITE FOR RESIDUE EDO A 186 source : AC6 26) chain B residue 86 type sequence G description BINDING SITE FOR RESIDUE EDO A 186 source : AC6 27) chain B residue 41 type sequence I description BINDING SITE FOR RESIDUE PHU B 201 source : AC7 28) chain B residue 123 type sequence F description BINDING SITE FOR RESIDUE PHU B 201 source : AC7 29) chain B residue 132 type sequence Y description BINDING SITE FOR RESIDUE PHU B 201 source : AC7 30) chain B residue 134 type sequence K description BINDING SITE FOR RESIDUE PHU B 201 source : AC7 31) chain B residue 8 type sequence I description BINDING SITE FOR RESIDUE SO4 B 206 source : AC8 32) chain B residue 75 type sequence K description BINDING SITE FOR RESIDUE SO4 B 206 source : AC8 33) chain B residue 164 type sequence N description BINDING SITE FOR RESIDUE SO4 B 206 source : AC8 34) chain B residue 165 type sequence H description BINDING SITE FOR RESIDUE SO4 B 206 source : AC8 35) chain B residue 52 type sequence Y description BINDING SITE FOR RESIDUE CL B 183 source : AC9 36) chain B residue 54 type sequence T description BINDING SITE FOR RESIDUE CL B 183 source : AC9 37) chain B residue 134 type sequence K description BINDING SITE FOR RESIDUE CL B 183 source : AC9 38) chain B residue 138 type sequence Y description BINDING SITE FOR RESIDUE CL B 183 source : AC9 39) chain B residue 81 type sequence R description BINDING SITE FOR RESIDUE SO4 B 184 source : BC1 40) chain B residue 106 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 184 source : BC1 41) chain B residue 134 type sequence K description BINDING SITE FOR RESIDUE SO4 B 184 source : BC1 42) chain C residue 41 type sequence I description BINDING SITE FOR RESIDUE PHU C 201 source : BC2 43) chain C residue 123 type sequence F description BINDING SITE FOR RESIDUE PHU C 201 source : BC2 44) chain C residue 125 type sequence K description BINDING SITE FOR RESIDUE PHU C 201 source : BC2 45) chain C residue 132 type sequence Y description BINDING SITE FOR RESIDUE PHU C 201 source : BC2 46) chain A residue 164 type sequence N description BINDING SITE FOR RESIDUE SO4 C 206 source : BC3 47) chain A residue 165 type sequence H description BINDING SITE FOR RESIDUE SO4 C 206 source : BC3 48) chain C residue 75 type sequence K description BINDING SITE FOR RESIDUE SO4 C 206 source : BC3 49) chain C residue 93 type sequence T description BINDING SITE FOR RESIDUE EDO C 183 source : BC4 50) chain C residue 94 type sequence L description BINDING SITE FOR RESIDUE EDO C 183 source : BC4 51) chain C residue 106 type sequence Y description BINDING SITE FOR RESIDUE EDO C 183 source : BC4 52) chain C residue 54 type sequence T description BINDING SITE FOR RESIDUE CL C 184 source : BC5 53) chain C residue 138 type sequence Y description BINDING SITE FOR RESIDUE CL C 184 source : BC5 54) chain C residue 79 type sequence W description BINDING SITE FOR RESIDUE SO4 C 185 source : BC6 55) chain C residue 81 type sequence R description BINDING SITE FOR RESIDUE SO4 C 185 source : BC6 56) chain C residue 106 type sequence Y description BINDING SITE FOR RESIDUE SO4 C 185 source : BC6 57) chain C residue 134 type sequence K description BINDING SITE FOR RESIDUE SO4 C 185 source : BC6 58) chain B residue 23 type sequence Q description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 59) chain B residue 26 type sequence Q description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 60) chain C residue 26 type sequence Q description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 61) chain C residue 115 type sequence Y description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 62) chain C residue 116 type sequence N description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 63) chain C residue 140 type sequence R description BINDING SITE FOR RESIDUE PHU C 186 source : BC7 64) chain A residue 55 type sequence I description BINDING SITE FOR RESIDUE SO4 C 187 source : BC8 65) chain A residue 175 type sequence C description BINDING SITE FOR RESIDUE SO4 C 187 source : BC8 66) chain C residue 129 type sequence N description BINDING SITE FOR RESIDUE SO4 C 187 source : BC8 67) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE SO4 C 188 source : BC9 68) chain C residue 25 type sequence N description BINDING SITE FOR RESIDUE SO4 C 188 source : BC9 69) chain C residue 26 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 188 source : BC9 70) chain A residue 52 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI1 71) chain B residue 52 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI1 72) chain C residue 52 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI1 73) chain A residue 106 type BINDING sequence Y description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 74) chain A residue 134 type BINDING sequence K description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 75) chain B residue 106 type BINDING sequence Y description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 76) chain B residue 134 type BINDING sequence K description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 77) chain C residue 106 type BINDING sequence Y description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 78) chain C residue 134 type BINDING sequence K description BINDING => ECO:0007744|PDB:3CMP source Swiss-Prot : SWS_FT_FI2 79) chain A residue 125 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 80) chain A residue 138 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 81) chain B residue 125 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 82) chain B residue 138 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 83) chain C residue 125 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 84) chain C residue 138 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U source Swiss-Prot : SWS_FT_FI3 85) chain A residue 21-34 type prosite sequence NFQDNQFQGKWYVV description LIPOCALIN Lipocalin signature. NFQdnQFQGKWYVV source prosite : PS00213 86) chain A residue 65 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS source Swiss-Prot : SWS_FT_FI5 87) chain B residue 65 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS source Swiss-Prot : SWS_FT_FI5 88) chain C residue 65 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS source Swiss-Prot : SWS_FT_FI5

Display surface Download Links