eF-site ID 3tz7-B
PDB Code 3tz7
Chain B

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Title Kinase domain of cSrc in complex with RL103
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Proto-oncogene tyrosine-protein kinase Src
Source Gallus gallus (Chicken) (SRC_CHICK)
Sequence B:  KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKT
LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI
VTEYMSKGCLLDFLKGEMGKYLRLPQLVDMAAQIASGMAY
VERMNYVHRDLRAANILVGENLVCKVADFGFPIKWTAPEA
ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD
QVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQ
AFLEDYFTSTEPQYQPGENL
Description


Functional site

1) chain B
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

2) chain B
residue 293
type
sequence A
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

3) chain B
residue 310
type
sequence E
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

4) chain B
residue 339
type
sequence E
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

5) chain B
residue 340
type
sequence Y
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

6) chain B
residue 341
type
sequence M
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

7) chain B
residue 348
type
sequence D
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

8) chain B
residue 403
type
sequence A
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

9) chain B
residue 404
type
sequence D
description BINDING SITE FOR RESIDUE AQB B 601
source : AC2

10) chain B
residue 527
type MOD_RES
sequence Y
description Phosphotyrosine; by CSK => ECO:0000269|PubMed:2420005
source Swiss-Prot : SWS_FT_FI7

11) chain B
residue 436
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8856081
source Swiss-Prot : SWS_FT_FI5

12) chain B
residue 498
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000269|PubMed:19948721
source Swiss-Prot : SWS_FT_FI6

13) chain B
residue 386
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

14) chain B
residue 273
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

15) chain B
residue 295
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3


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