eF-site ID 3tq0-A PDB Code 3tq0 Chain A click to enlarge Title Crystal structure of Leishmania major dihydroorotate dehydrogenase in complex with fumarate Classification OXIDOREDUCTASE Compound Dihydroorotate dehydrogenase Source Leishmania major (Q4QEW7_LEIMA) Sequence A:  SMSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASG SLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDF YLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVAT EKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYP HSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGN GLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYR RCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEG PSIFERLTSELLGVMAKKRYQTLDEFRGKVRTL Description Functional site 1) chain A residue 19 type sequence A description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 2) chain A residue 20 type sequence A description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 3) chain A residue 21 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 4) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 5) chain A residue 45 type sequence S description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 6) chain A residue 59 type sequence Y description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 7) chain A residue 68 type sequence N description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 8) chain A residue 70 type sequence M description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 9) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 10) chain A residue 165 type sequence K description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 11) chain A residue 194 type sequence I description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 12) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 13) chain A residue 222 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 14) chain A residue 223 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 15) chain A residue 226 type sequence V description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 16) chain A residue 249 type sequence C description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 17) chain A residue 250 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 18) chain A residue 251 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 19) chain A residue 272 type sequence G description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 20) chain A residue 273 type sequence T description BINDING SITE FOR RESIDUE FMN A 313 source : AC1 21) chain A residue 44 type sequence K description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 22) chain A residue 68 type sequence N description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 23) chain A residue 70 type sequence M description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 24) chain A residue 71 type sequence G description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 25) chain A residue 72 type sequence L description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 26) chain A residue 128 type sequence N description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 27) chain A residue 131 type sequence C description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 28) chain A residue 132 type sequence P description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 29) chain A residue 133 type sequence N description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 30) chain A residue 195 type sequence N description BINDING SITE FOR RESIDUE FUM A 314 source : AC2 31) chain A residue 202 type sequence V description BINDING SITE FOR RESIDUE GOL A 315 source : AC3 32) chain A residue 203 type sequence I description BINDING SITE FOR RESIDUE GOL A 315 source : AC3 33) chain A residue 159 type sequence P description BINDING SITE FOR RESIDUE SO4 A 317 source : AC5 34) chain A residue 160 type sequence H description BINDING SITE FOR RESIDUE SO4 A 317 source : AC5 35) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE SO4 A 317 source : AC5 36) chain A residue 159 type sequence P description BINDING SITE FOR RESIDUE SO4 A 318 source : AC6 37) chain A residue 187 type sequence K description BINDING SITE FOR RESIDUE SO4 A 318 source : AC6 38) chain A residue 239 type sequence R description BINDING SITE FOR RESIDUE SO4 A 319 source : AC7 39) chain A residue 311 type sequence T description BINDING SITE FOR RESIDUE SO4 A 319 source : AC7 40) chain A residue 238 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 320 source : AC8 41) chain A residue 306 type sequence R description BINDING SITE FOR RESIDUE SO4 A 320 source : AC8 42) chain A residue 227 type sequence L description BINDING SITE FOR RESIDUE GOL B 315 source : BC2 43) chain A residue 231 type sequence L description BINDING SITE FOR RESIDUE GOL B 315 source : BC2

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