eF-site ID 3tks-ABCDE PDB Code 3tks Chain A, B, C, D, E click to enlarge Title Crystal structure of full-length human peroxiredoxin 4 in three different redox states Classification OXIDOREDUCTASE Compound Peroxiredoxin-4 Source Homo sapiens (Human) (PRDX4_HUMAN) Sequence A:  HLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFF FYPLDFTFVXPTEIIAFGDRLEEFRSINTEVVACSVDSQF THLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLED SGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQA FQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN B:  HLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFF FYPLDFTFVXPTEIIAFGDRLEEFRSINTEVVACSVDSQF THLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLED SGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQA FQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN C:  HLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFF FYPLDFTFVXPTEIIAFGDRLEEFRSINTEVVACSVDSQF THLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLED SGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQA FQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN D:  HLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFF FYPLDFTFVXPTEIIAFGDRLEEFRSINTEVVACSVDSQF THLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLED SGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQA FQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN E:  HLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFF FYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQF THLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLED SGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQA FQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN Description Functional site 1) chain A residue 163 type sequence R description BINDING SITE FOR RESIDUE PER A 235 source : AC1 2) chain A residue 182 type sequence L description BINDING SITE FOR RESIDUE PER A 235 source : AC1 3) chain C residue 85 type sequence F description BINDING SITE FOR RESIDUE PER C 235 source : AC2 4) chain C residue 86 type sequence V description BINDING SITE FOR RESIDUE PER C 235 source : AC2 5) chain C residue 87 type sequence X description BINDING SITE FOR RESIDUE PER C 235 source : AC2 6) chain C residue 163 type sequence R description BINDING SITE FOR RESIDUE PER C 235 source : AC2 7) chain D residue 85 type sequence F description BINDING SITE FOR RESIDUE PER D 235 source : AC3 8) chain D residue 86 type sequence V description BINDING SITE FOR RESIDUE PER D 235 source : AC3 9) chain D residue 87 type sequence X description BINDING SITE FOR RESIDUE PER D 235 source : AC3 10) chain D residue 163 type sequence R description BINDING SITE FOR RESIDUE PER D 235 source : AC3 11) chain E residue 87 type ACT_SITE sequence C description Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:12059788, ECO:0000305|PubMed:21916849 source Swiss-Prot : SWS_FT_FI1 12) chain D residue 87 type ACT_SITE sequence X description Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:12059788, ECO:0000305|PubMed:21916849 source Swiss-Prot : SWS_FT_FI1

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