eF-site ID 3tkj-AB PDB Code 3tkj Chain A, B click to enlarge Title Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala Classification HYDROLASE Compound L-asparaginase Source Homo sapiens (Human) (ASGL1_HUMAN) Sequence A:  GNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILRE GGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDAS IMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHELGAVGA VALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADN DIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLS LGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDG KLHFGIDPDDTTITDLP B:  GNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILRE GGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDAS IMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHELGAVGA VALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADN DIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLS LGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDG KLHFGIDPDDTTITDLP Description Functional site 1) chain A residue 55 type sequence L description BINDING SITE FOR RESIDUE NA A 401 source : AC1 2) chain A residue 56 type sequence E description BINDING SITE FOR RESIDUE NA A 401 source : AC1 3) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE NA A 401 source : AC1 4) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE NA A 401 source : AC1 5) chain A residue 63 type sequence A description BINDING SITE FOR RESIDUE NA A 401 source : AC1 6) chain A residue 65 type sequence C description BINDING SITE FOR RESIDUE NA A 401 source : AC1 7) chain A residue 1 type sequence G description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 8) chain A residue 2 type sequence N description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 9) chain A residue 3 type sequence P description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 10) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 11) chain B residue 57 type sequence D description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 12) chain B residue 100 type sequence N description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 13) chain A residue 186 type sequence T description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 14) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 15) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 16) chain A residue 198 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 17) chain A residue 199 type sequence D description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 18) chain A residue 200 type sequence S description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 19) chain A residue 222 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 20) chain B residue 55 type sequence L description BINDING SITE FOR RESIDUE NA B 401 source : AC4 21) chain B residue 56 type sequence E description BINDING SITE FOR RESIDUE NA B 401 source : AC4 22) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE NA B 401 source : AC4 23) chain B residue 61 type sequence F description BINDING SITE FOR RESIDUE NA B 401 source : AC4 24) chain B residue 63 type sequence A description BINDING SITE FOR RESIDUE NA B 401 source : AC4 25) chain B residue 65 type sequence C description BINDING SITE FOR RESIDUE NA B 401 source : AC4 26) chain B residue 2 type sequence N description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 27) chain B residue 3 type sequence P description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 28) chain B residue 35 type sequence Y description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 29) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 30) chain B residue 289 type sequence K description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 31) chain B residue 290 type sequence D description BINDING SITE FOR RESIDUE TAM B 402 source : AC5 32) chain B residue 186 type sequence T description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 33) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 34) chain B residue 196 type sequence R description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 35) chain B residue 198 type sequence G description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 36) chain B residue 199 type sequence D description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 37) chain B residue 200 type sequence S description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 38) chain B residue 222 type sequence G description BINDING SITE FOR RESIDUE SO4 B 403 source : AC6 39) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 40) chain A residue 219 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 41) chain B residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 42) chain B residue 219 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2 43) chain A residue 168 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:22861376 source Swiss-Prot : SWS_FT_FI1 44) chain B residue 168 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:22861376 source Swiss-Prot : SWS_FT_FI1

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