eF-site ID 3tkj-A PDB Code 3tkj Chain A click to enlarge Title Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala Classification HYDROLASE Compound L-asparaginase Source Homo sapiens (Human) (ASGL1_HUMAN) Sequence A:  GNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILRE GGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDAS IMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHELGAVGA VALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADN DIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLS LGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDG KLHFGIDPDDTTITDLP Description Functional site 1) chain A residue 55 type sequence L description BINDING SITE FOR RESIDUE NA A 401 source : AC1 2) chain A residue 56 type sequence E description BINDING SITE FOR RESIDUE NA A 401 source : AC1 3) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE NA A 401 source : AC1 4) chain A residue 61 type sequence F description BINDING SITE FOR RESIDUE NA A 401 source : AC1 5) chain A residue 63 type sequence A description BINDING SITE FOR RESIDUE NA A 401 source : AC1 6) chain A residue 65 type sequence C description BINDING SITE FOR RESIDUE NA A 401 source : AC1 7) chain A residue 1 type sequence G description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 8) chain A residue 2 type sequence N description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 9) chain A residue 3 type sequence P description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 10) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE TAM A 402 source : AC2 11) chain A residue 186 type sequence T description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 12) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 13) chain A residue 196 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 14) chain A residue 198 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 15) chain A residue 199 type sequence D description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 16) chain A residue 200 type sequence S description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 17) chain A residue 222 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 18) chain A residue 168 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:19839645, ECO:0000269|PubMed:22861376 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 196 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 20) chain A residue 219 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI2

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