eF-site ID 3tcp-B PDB Code 3tcp Chain B click to enlarge Title Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase Mer Source Homo sapiens (Human) (MERTK_HUMAN) Sequence B:  KLEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAV KTMKEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILP FMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME YLSNRNFLHRDLAARNCMLRDDMTVCVADFMPVKWIAIES LADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLR LQLEKLLESL Description Functional site 1) chain B residue 843 type sequence D description BINDING SITE FOR RESIDUE CA A 12 source : AC3 2) chain B residue 617 type sequence A description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 3) chain B residue 672 type sequence P description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 4) chain B residue 674 type sequence M description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 5) chain B residue 675 type sequence K description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 6) chain B residue 677 type sequence G description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 7) chain B residue 727 type sequence R description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 8) chain B residue 728 type sequence N description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 9) chain B residue 730 type sequence M description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 10) chain B residue 687 type sequence R description BINDING SITE FOR RESIDUE CL B 865 source : AC6 11) chain B residue 802 type sequence P description BINDING SITE FOR RESIDUE CL B 3 source : AC7 12) chain B residue 820 type sequence K description BINDING SITE FOR RESIDUE CL B 3 source : AC7 13) chain B residue 821 type sequence Q description BINDING SITE FOR RESIDUE CA B 11 source : AC8 14) chain B residue 827 type sequence D description BINDING SITE FOR RESIDUE CA B 11 source : AC8 15) chain B residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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