eF-site ID 3tcp-AB PDB Code 3tcp Chain A, B click to enlarge Title Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase Mer Source Homo sapiens (Human) (MERTK_HUMAN) Sequence A:  LEDVVIDRNLLILGKILGSVMEGNLKQEDGTSLKVAVKTM KLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEPKP MVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPVKWI AIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTF SVLRLQLEKLLESLPD B:  KLEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAV KTMKEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILP FMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME YLSNRNFLHRDLAARNCMLRDDMTVCVADFMPVKWIAIES LADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLR LQLEKLLESL Description Functional site 1) chain A residue 601 type sequence V description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 2) chain A residue 617 type sequence A description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 3) chain A residue 672 type sequence P description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 4) chain A residue 674 type sequence M description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 5) chain A residue 675 type sequence K description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 6) chain A residue 677 type sequence G description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 7) chain A residue 727 type sequence R description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 8) chain A residue 728 type sequence N description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 9) chain A residue 730 type sequence M description BINDING SITE FOR RESIDUE CKJ A 1 source : AC1 10) chain A residue 820 type sequence K description BINDING SITE FOR RESIDUE CL A 865 source : AC2 11) chain A residue 843 type sequence D description BINDING SITE FOR RESIDUE CA A 12 source : AC3 12) chain B residue 843 type sequence D description BINDING SITE FOR RESIDUE CA A 12 source : AC3 13) chain A residue 827 type sequence D description BINDING SITE FOR RESIDUE CA A 13 source : AC4 14) chain B residue 617 type sequence A description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 15) chain B residue 672 type sequence P description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 16) chain B residue 674 type sequence M description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 17) chain B residue 675 type sequence K description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 18) chain B residue 677 type sequence G description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 19) chain B residue 727 type sequence R description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 20) chain B residue 728 type sequence N description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 21) chain B residue 730 type sequence M description BINDING SITE FOR RESIDUE CKJ B 2 source : AC5 22) chain B residue 687 type sequence R description BINDING SITE FOR RESIDUE CL B 865 source : AC6 23) chain B residue 802 type sequence P description BINDING SITE FOR RESIDUE CL B 3 source : AC7 24) chain B residue 820 type sequence K description BINDING SITE FOR RESIDUE CL B 3 source : AC7 25) chain B residue 821 type sequence Q description BINDING SITE FOR RESIDUE CA B 11 source : AC8 26) chain B residue 827 type sequence D description BINDING SITE FOR RESIDUE CA B 11 source : AC8 27) chain A residue 593-619 type prosite sequence LGSVMEGNLKQEDGTSLKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGSVMeGnlkqedgtslk.......VAVK source prosite : PS00107 28) chain A residue 719-731 type prosite sequence FLHRDLAARNCML description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCML source prosite : PS00109 29) chain A residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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